Oloa

O le porotini o le cerebral dopamine neurotrophic factor (CDNF) ua faʻaalia e puipuia ai le ala dopaminergic nigrostriatal pe a tuʻuina atu e pei o tui i totonu o le iole ma faʻataʻitaʻiga o le maʻi o Parkinson (PD).I lenei suʻesuʻega, na matou suʻesuʻeina le aʻafiaga o le neuroprotective o le CDNF na tuʻuina atu faʻatasi ma le adeno-associated viral (AAV) serotype 2 vector i le rat 6-hydroxydopamine (6-OHDA) faʻataʻitaʻiga o le PD.AAV2 vectors encoding CDNF, glial cell line-derived neurotrophic factor (GDNF), poʻo le polotini fluorescent lanu meamata na tui i totonu o le rat striatum.O suʻesuʻega faʻamatalaga o polotini na faʻaalia ai o le matou AAV2 veve na tuʻuina atu ma le lelei le neurotrophic factor genes i totonu o le faiʻai ma faʻaalia ai se faʻaaliga umi o polotini.Lua vaiaso talu ona uma le tui o le AAV2, na tui le 6-OHDA i totonu o le rat striatum, ma faʻatupu ai le faʻasolosolo faʻasolosolo o le nigrostriatal dopaminergic system.Togafitiga ma le AAV2-CDNF na mafua ai le faʻaitiitia o le amphetamine-induced ipsilateral rotations ae naʻo le puipuiga o le tyrosine hydroxylase (TH) -immunoreactive sela i le rat substantia nigra pars compacta ma TH-reactive fibers i le striatum.O fa'ai'uga mai lenei su'esu'ega e maua ai fa'amaoniga fa'aopoopo e mafai ona manatu le CDNF o se togafiti fa'ama'i ole ma'i Parkinson.