Oloa

Ina ia faʻamalamalamaina le faʻagasologa muamua o le mineralization dentin, na suʻesuʻeina le aʻafiaga faʻafefe o le 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) i le mineralization dentin.Iole (100 g) na tui i lalo o le paʻu ile HEBP (8 mg P / kg) mo le 7 poʻo le 14 d, ma faʻapipiʻi le tui mo Ca histochemistry ma / poʻo le microscopy electron.Na fa'aalia e tui fa'aapefa'i e pei o se apefa'i laina o nifo minerale ma e le'i fa'asalaina ile pito apical.O le GBHA na fa'aalia ai le feololo o le Ca i totonu o le matrix circumpulpal dentin matrix lea na fa'aalia ai e le microscopy eletonika le tele o le tufatufaina atu o mea fa'aeletonika e pei o mata.E le'o fa'ameamea le matrix dentin matrix e le lelei mo Ca ae o lo'o i ai le tele o matrix vesicles (MVs) fa'atumu i fa'amea tioata ma/po'o amorphous minerale teuina.O le mineralization ole circumpulpal dentin na tupu tuto'atasi ile MV-rich mantle dentin layer i fa'ata'ita'iga ua a'afia.O a matou fa'amaumauga o lo'o tu'uina atu ai fa'amaoniga fa'asolopito o mea totino e mafai ona tu'u ai Ca o le circumpulpal dentin matrix ma lona toesea i le mantle dentin o lo'o tupu ai le MV-mediated mineralization.I totonu o le mantle dentin, HEBP e le faʻalavelaveina le tuputupu aʻe tioata i MVs ae faʻalavelaveina lona tupu aʻe pe a maeʻa le malepelepe.O lo'o fa'ailoa mai o le circumpulpal dentin matrix e iai le malosi e fa'a'ele'ele ese ai mai le MV-mediated mineralization o mantle dentin, e ui o MV e fa'amauina le nofoaga muamua ma le taimi o le fa'aputuina o nifo.