Oloa

Fa'agaoioi le thrombin-activatable fibrinolysis inhibitor (TAFIa) o se carboxypeptidase o lo'o i ai le zinc ma e matua taofia ai le fibrinolysis.O lo'o fa'apea ona fa'amoemoeina le fa'atosina o le TAFIa e fai ma sui o le profibrinolytic.Na matou lipotia talu ai nei le mamanu ma le tuʻufaʻatasia o inhibitors o loʻo i ai seleni o le TAFIa ma a latou gaioiga faʻalavelave.O iinei matou te lipotia ai le fausaga tioata o seleni malosi, sulfur-, ma le phosphinic acid-containing inhibitors o loʻo fusia i porcine pancreatic carboxypeptidase B (ppCPB).ppCPB ose TAFIa homologue ma sui TAFIa mo su'esu'ega tioata.O fausaga tioata o le ppCPB faʻapipiʻiina ma le seleni 1a, lona sulfur analogue 2, ma le phosphinic acid derivative EF6265 na fuafuaina i le 1.70, 2.15, ma le 1.90 Å iugafono.O inhibitor ta'itasi e fusifusia i le nofoaga galue o le ppCPB i se faiga tutusa ma le mea na matauina mo inhibitors lipotia muamua.O lea la, i lavelave, seleni, sulfur, ma phosphinic acid okesene faamaopoopo i le zinc i le ppCPB.Ole fa'aaliga muamua lea ma lipoti ole seleni fa'atasi ile zinc ile CPB.