Oloa

ATP-gated P2X3 receptors o ni transducers taua o le nociceptive stimuli ma e toetoe lava a faʻaalia e neu ganglion sensory.I le kiore trigeminal ganglion (TG), o le P2X3 receptor galuega e faʻafuaseʻi ona faʻaleleia e le pharmacological poloka o le natriuretic peptide receptor-A (NPR-A), o loʻo faʻamatalaina ai se tulaga faʻalavelave faʻalavelave o peptides natriuretic endogenous i nociception mediated e P2X3 receptors.O le leai o se suiga i le P2X3 protein expression o loʻo faʻaalia ai le faʻaogaina o le faʻaogaina o le faʻaogaina o le faʻaogaina o le P2X3 o loʻo tumau pea le le manino. poloka anantin.O le mea lea, na matou suʻesuʻeina suiga i le tufatufaina atu o le P2X3 i totonu o le lipid raft membrane compartment, o latou tulaga phosphorylation, faʻapea foʻi ma a latou galuega i le faʻapipiʻiina o patch.O le tuai ona amata o le P2X3 desensitization o se tasi lea o masini mo le faʻaleleia o le anantin-induced o le gaioiga P2X3.O le anant i le talosaga na mafua ai le toe tufatufaina atu o le talisuaga o le P2X3 i le vaega o le lipid raft ma faʻaititia le P2X3 serine phosphorylation, e lua mea faʻapitoa e le faʻalagolago.O se inhibitor o cGMP-faalagolago polotini kinase ma siRNA-mediated knockdown o le BNP faʻataʻitaʻiina le aʻafiaga o anantin.We faʻaalia i le kiore trigeminal neurons endogenous BNP galue i luga ole NPR-A receptors e fuafua ai le atuatuvale constitutive o P2X3 receptor galuega.Tonic inhibition of P2X3 receptor activity by BNP/NPR-A/PKG auala e tupu e ala i ni auala ma'oti se lua: P2X3 serine phosphorylation ma le toe tufatufaina atu o le tali i vaega e le o se va'a.O lenei faiga fou o le faʻatonutonuina o le tali e mafai ona avea ma taulaʻiga mo suʻesuʻega i le lumanaʻi e faʻatatau i le faʻaitiitia o le faʻaogaina o le P2X3 gaioiga faʻamaʻi i tiga masani.