Oloa

O le Neuroblastoma, o le kanesa o le tino faʻaalofa, o le tumo malosi faʻapitoa e sili ona taatele i tamaiti.O le faʻalauteleina o le MYCN ma le faʻateleina o le BDNF / TrkB faʻailoga o foliga ia o tuma maualuga;ae, e na'o le ˜25% o tuma ma'i e fa'aalia nei uiga.O le mea lea, o le faʻamaoniaina o isi biomarkers ma togafitiga faʻapitoa e taua.I le avea ai o le aminoacylase 1 (ACY1), o le amino acid deacetylase, o se mea e taofia ai le tumo i totonu o mama sela laiti ma fatuga o fatu, na matou suʻesuʻeina pe mafai e isi tagata o le aiga aspartoacylase (ASPA, aminoacylase 2) poʻo aminoacylase 3 (ACY3) ona aoga. se galuega tutusa i le neuroblastoma.Aminoacylase faʻamatalaga na suʻesuʻeina i le TrkB-lelei, MYCN-faʻateleina (SMS-KCNR ma SK-N-BE) ma le TrkB-le lelei, le-MYCN-faʻateleina (SK-N-AS, SK-N-SH, SH-SY5Y ma SH-EP) laina sela neuroblastoma.O aminoacylase ta'itasi na fa'aalia ai le va'aiga fa'avanoa ma'oti (e pei o le cytosolic ACY1, ASPA e feso'ota'i membrane ma le ACY3 faaniukilia).Ina ua togafitia sela SK-N-SH i neural differentiation agents (eg, retinoic acid ma le cAMP) i ala o faasalalauga o loʻo i ai le 10% serum, ACY1 na o le pau lea o le aminoacylase o lona faʻaaliga na faʻasalaina.O le ASPA na fa'aalia muamua i sela SH-EP o se glial sublineage.ACY3 na sili atu ona faʻaalia i le TrkB-lelei, MYCN-faʻateleina laina.O aminoacylases uma e tolu na faʻaalia i le tino masani o le tagata, o se nofoaga masani o le neuroblastoma, ae naʻo le ACY1 ma le ACY3 na faʻaalia le faʻaalia i le tumo neuroblastoma muamua.Bioinformatics data mining o Kaplan-Meier survival na faʻaalia ai o le maualuga o le ACY3 faʻamatalaga e fesoʻotaʻi ma le le lelei o faʻataʻitaʻiga, ae o le maualalo o le faʻaaliga o le ACY1 poʻo le ASPA e fesoʻotaʻi ma le le lelei o faʻamaʻi.O nei faʻamatalaga e faʻaalia ai o le faʻamatalaga aminoacylase e faʻaleagaina i le neuroblastoma