Oloa

NADPH oxidases o se aiga o enzymes e faʻatupuina ituaiga okesene faʻafoʻi (ROS).O le NOX1 (NADPH oxidase 1) ma le NOX2 oxidases o punavai autu ia o le ROS i totonu o le alatoto puipui i tulaga e pei o le toto maualuga, hypercholesterolaemia, maʻisuka ma le matua, ma o lea e taua tele ai i latou i le faʻamaʻi faʻamaʻi, faʻaleagaina o le endothelial ma le mumū o le toto o loʻo i lalo. toe fa'aleleia o alatoto ma le atherogenesis.I lenei Iloiloga, matou te faʻalauteleina le manatu e faʻatusatusa i le faʻaogaina o antioxidants masani, faʻasaina NOX1 ma NOX2 oxidases o se auala sili atu mo le faʻafefeina o faʻamaʻi faʻamaʻi.Matou te faʻamatala faʻapuupuu nisi o mea masani ma faʻaalia mai le NADPH oxidase inhibitors.E le gata i lea, matou te faʻamaonia le taua tele o le NADPH oxidase regulatory subunit, p47phox, i le gaioiga o vascular NOX1 ma NOX2 oxidases, ma fautua atu pe faʻapefea ona sili atu le malamalama i ana fegalegaleaiga mole faʻapitoa e mafai ai le atinaʻeina o vailaʻau isoform-filifiliga e puipuia ai. pe togafitia faʻamaʻi fatu fatu.