4-Nitrophenyl phosphate disodium masima 6-hydrate CAS:333338-18-4 paʻepaʻe i le paʻu samasama sesega
| Numera Fa'amaumauga | XD90511 |
| Igoa Oloa | 4-Nitrophenyl phosphate disodium masima 6-hydrate |
| CAS | 333338-18-4 |
| Fuafua mole | C6H16NNa2O12P |
| Molecular Weight | 371.142 |
| Fa'amatalaga Teuina | Ambient |
| Fa'atonu Fa'asologa o Fa'asologa | 29199000 |
Fa'amatalaga o oloa
| Fa'aaliga | pa'epa'e i le samasama samasama |
| Su'ega | 99% |
E sili atu i le 70% o gliomas maualalo o loʻo tauaveina se suiga R132H heterozygous i le gene coding mo isocitrate dehydrogenase 1 (IDH1).O lenei mea e tuʻuina atu ai le enzyme ma le malosi fou e faʻaliliu ai le α-ketoglutarate i le 2-hydroxyglutarate, ma iu ai ina oʻo atu i le tumorigenesis.O le puna tele o le gaosiga o le 2-hydroxyglutarate o le glutamine, lea, i le kanesa, o se punavai foi mo le tricarboxylic acid cycle (TCA) anaplerosis.Ole isi fa'apogai ole anaplerosis ole pyruvate flux e ala ile pyruvate carboxylase (PC), ose auala masani ile astrocytes masani.O le sini o lenei suʻesuʻega o le fuafuaina lea pe avea le PC ma puna o le TCA anaplerosis i sela mutant IDH1 lea e faʻaaogaina ai le glutamine mo le gaosiga o le 2-hydroxyglutarate. Na suʻesuʻeina astrocytes masani a le tagata olaola e faʻaalia le heterozygous mutant IDH1 poʻo le wild-type IDH1.O le fa'afefe o le pyruvate e ala ile PC ma le pyruvate dehydrogenase (PDH) na fuafuaina ile fa'aogaina o le fa'amaneta resonance spectroscopy e su'esu'e ai le fa'ailoga o le [2-¹³C] ¹³C-labe led glutamate ma le glutamine e maua mai i le kulukose.O su'esu'ega o gaioiga, RT-PCR ma le poloka i sisifo na fa'aogaina e su'esu'e ai le fa'aaliga ma le gaioiga o enzymes talafeagai.O faʻamaumauga o le Cancer Genome Atlas (TCGA) na suʻesuʻeina e iloilo ai le faʻaalia o enzymes i faʻataʻitaʻiga glioma tagata. Faʻatusatusa i sela o le vao, mutant IDH1 sela na faʻateleina le faʻatupuina o le vaeluaga e ala i le PC.O lenei mea na fesoʻotaʻi ma se faʻaopoopoga tele o gaioiga ma faʻamatalaga PC.I le taimi lava e tasi, o le gaioiga a le PDH na matua faʻaitiitia, atonu na faʻatalanoaina e ala i le faʻateleina o le faʻaogaina o le PDH phosphorylation e le PDH kinase 3. E ogatasi ma le mataʻituina i sela, o le auiliiliga o faʻamatalaga TCGA na faʻaalia ai se faʻaopoopoga tele o faʻamatalaga PC i mutant IDH-faʻaalia faʻataʻitaʻiga glioma tagata faʻatusatusa i le vao- type IDH.O matou suʻesuʻega o loʻo fautua mai ai o suiga i le PC ma le PDH atonu o se vaega taua o le faʻaogaina o le telefoni feaveaʻi i le suiga o le IDH1 ma e mafai ona avea ma faʻamoemoega faʻapitoa.
