Oloa

Islet amyloid polypeptide (IAPP; ua ta'ua foi o le amylin) e nafa ma le fausiaina o le islet amyloid i le ma'isuka ituaiga 2, ma o le IAPP-fa'aoso oona e talitonuina e saofagā i le leiloa o le β-cell mass e fesoʻotaʻi ma faʻataʻitaʻiga tuai o le maʻisuka ituaiga 2.E mafai fo'i ona iai se sao ile fa'atupuina ole islet amyloid ile fa'aletonu ole sulu pe a mae'a fa'atupuina.O le IAPP e gaosia e pei o se prohormone, pro-islet amyloid polypeptide (proIAPP), ma faʻagasolo i totonu o mea lilo o le pancreatic β-cells.E maua vaega ole proIAPP ile teuina o amyloid;sili ona iloga o le 48-residue intermediate, proIAPP (1-48), lea e aofia ai le N-terminal pro-extension, ae ua maeʻa ona faʻagasolo lelei ile C-terminus.O le le atoatoa o gaioiga e mafai ona i ai se sao i le fausiaina o le amyloid islet e ala i le faʻalauiloaina o fegalegaleaiga ma sulfated proteoglycans o le extracellular matrix, lea, i le isi itu, e faʻamalosia ai le fausiaina o le amyloid.Matou te faʻaalia o le fuchsin acid (3-(1-(4-amino-3-methyl-5-sulphonatophenyl)-1-(4-amino-3-sulphonatophenyl)methylene)cyclohexa-1,4-dienesulphonic acid), o se mea faigofie. sulfonated triphenyl methyl derivative, o se inhibitor malosi o le fausia amyloid e le proIAPP(1-48) intermediate.O le triphenyl methane e sili ona lavelave e maua vave lanumeamata FCF {ethyl-[4-[[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl)methylidene]-1-cyclohexa -2,5-dienylidene]-[(3-sulfophenyl)methyl]azanium} e faʻalavelaveina foʻi le faʻavaeina o le amyloid e le IAPP ma le proIAPP process intermediate.O mea uma e lua e taofia ai le fausiaina o le amyloid e ala i faʻafefiloi o le proIAPP intermediate ma le faʻataʻitaʻiga glycosaminoglycan heparan sulfate.O le fuchsin acid e taofia ai foi le glycosaminoglycan-mediated amyloid formation e le IAPP matua.O le malosi e faʻalavelave ai le fausiaina o le amyloid e le naʻo le faʻaogaina o le sulfonated, talu ai o le inhibitor sulfonated o le amyloid-β, tramiprosate, e le o se inhibitor o le amyloid faʻavae e le proIAPP (1-48).