Oloa

Trans-1-(tert-Butoxycarbonyl)-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid o se vailaʻau vailaʻau o loʻo i ai le tele o faʻaoga talafeagai i le matata o le faʻaogaina o meaola ma suʻesuʻega vailaʻau.O loʻo faʻaalia i le i ai o se mama pyrrolidine e suitulaga i se vaega puipuia o tert-butoxycarbonyl (Boc) i luga o le nitrogen atom ma se vaega trifluoromethyl i luga o le mama phenyl.O se tasi o faʻaoga autu o le trans-1-(tert-Butoxycarbonyl) - 4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid o se mea faʻavauvau i le tuʻufaʻatasia o isi mea faʻalaʻau.O lona fausaga tulaga ese ma vaega galue e avea o se poloka fau fale tele mo le fausiaina o mole lavelave.O le vaega o le Boc e avea o se vaega puipuia, lea e mafai ona filifilia filifilia i lalo o tulaga faʻapitoa e faʻaalia e faʻaalia ai le nofoaga faʻafefe mo nisi suiga.O lenei mea e mafai ai mo suiga faʻaletino pulea ma saʻo.O le vaega trifluoromethyl i trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid e tuʻuina atu foʻi mea taua ma faʻaoga talafeagai.Trifluoromethyl vaega o loʻo lauiloa mo lo latou natura faʻateʻaina eletise ma le lipophilicity, lea e mafai ona faʻaleleia ai le malosi, faʻamautu o le metabolic, ma le bioavailability o sui tauva.E le gata i lea, e mafai e le vaega o le trifluoromethyl ona faʻaogaina mea faʻapitoa o le vailaʻau, e aʻafia ai le solubility, lipophilicity, ma le faʻapipiʻiina o fesoʻotaʻiga. e mafai ona fa'aalia le gaioioiga ola po'o se mea fa'ameamea.Prodrugs o mea fa'aletino e le gaioi e o'o i kemikolo po'o le enzymatic suiga i totonu o le tino e liua i vaila'au malosi.I nisi tulaga, e mafai ona filifilia le vaega puipuia o le Boc i vivo, faʻagaoioia le faʻapipiʻi e faʻaalia ai se manaʻoga togafitiga faʻapitoa. phenyl)pyrrolidine-3-carboxylic acid e tele, e manaʻomia nisi suʻesuʻega ma suʻesuʻega e suʻesuʻe ai lona gafatia atoatoa.E masani ona aofia ai le su'esu'eina o kemisi fa'afoma'i, su'esu'ega fa'a-gaioiga, ma su'esu'ega fa'aola.E ala i le malamalama lelei i mea totino ma le gaioiga, e mafai e saienitisi ona suʻesuʻeina lona talafeagai mo le faʻatatauina o faʻamaʻi poʻo tulaga faʻapitoa, e oʻo atu ai i le atinaʻeina o ni vailaʻau fou poʻo ni faʻamaʻi catalytic i le lumanaʻi.