Oloa

Methyl 1,2,3,4-tetra-O-acetyl-β-D-glucuronate ua faʻaaogaina i se suʻesuʻega e iloilo ai le mamanu ma le tuʻufaʻatasia o se vai-soluble glucuronide derivatives o camptothecin mo le kanesa prodrμg monotherapy ma antibody-directed enzyme prodrμg togafitiga.Na faʻaaogaina foi i se suʻesuʻega e suʻesuʻe ai le tuʻufaʻatasia ma le matafaioi a glycosylthio heterocycles i kemisi gaʻo.

Fa'asologa o mea e maua mai i le pentopyranic acid

N4-Benzoylcytosine 1- (methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate) ua maua mai i se fua o le 70% e ala i le glycosylation o le trimethylsilyl derivative o le N4-benzoylcytosine ma le methyl 1,2 ,3,4-tetra-O-acetyl-β-D-glucopyranuronate i le i ai o le tolu tutusa o le SnCl4 e fai ma sui condensing.Cytosine 1-(β-D-glucopyranosiduronamide) (IV) - le amide o le pentopyranic acid - ua faʻapipiʻiina i le faʻatusatusaina o fua faʻatatau e le ammonolysis o le nucleoside (I).