Oloa

Methyl 1- [(2'-cyanobiphenyl-4-yl) methyl] -2-ethoxy-1H-benzimidazole-7-carboxylate o se vailaʻau faʻamaʻi ma faʻaogaina faʻaoga i le tele o talosaga, aemaise lava i le fanua o vailaʻau. le aiga o benzimidazole derivatives, lea o loʻo suʻesuʻeina lautele mo o latou gafatia togafitiga.Benzimidazoles ua maua e faʻaalia ai le tele o gaioiga faʻapitoa, e aofia ai le faʻamaʻi, antifungal, antibacterial, antiviral, ma anti-inflammatory properties.Methyl 1- [(2'-cyanobiphenyl-4-yl) methyl] -2-ethoxy-1H -benzimidazole-7-carboxylate e mafai ona avea o se fata poʻo se fausaga autu mo le mamanu ma le atinaʻeina o vailaʻau fou.O lona fausaga vaila'au fa'apitoa e maua ai avanoa mo le fa'aleleia atili ma le fa'aleleia atili e fa'aleleia ai gaioiga fa'afoma'i mana'omia po'o le fa'atatauina o ala fa'ama'i.E mafai e fomaʻi vailaʻau ona faʻaogaina lenei mea e fai ma amataga mo le faʻapipiʻiina o molelaʻau fou ma ni faʻaoga faʻapitoa faʻapitoa.O nei suiga e mafai ona faʻaleleia atili ai le faʻaogaina o le faʻaogaina o faʻamaʻi faʻamaʻi poʻo mole mole mole, e oʻo atu ai i le atinaʻeina o vailaʻau sili atu ona aoga. E mafai ona faia faʻataʻitaʻiga ma suʻesuʻega e iloilo ai le gaioiga o meaola faʻaogaina e faʻaogaina ai in vitro cell-based assays poʻo in vivo manu faʻataʻitaʻiga.O lenei mea e mafai ona tuʻuina atu ai faʻamatalaga taua i ana faʻaoga faʻapitoa faʻapitoa ma taʻitaʻia atili ai le faʻaleleia atili. E le gata i lea, o lenei tuufaatasiga e mafai ona avea o se meafaigaluega taua i le suʻesuʻeina o le fausaga-gaioiga sootaga (SAR) o benzimidazole derivatives.E ala i le tu'ufa'atasia o analog ma fesuiaiga i filifili i itu po'o vaega fa'atino, e mafai e saienitisi ona maua se malamalamaga sili atu pe fa'afefea ona a'afia le gaioiga ma le filifilia o le fa'atulagaga fa'apitoa.O lenei malamalama e mafai ona fesoasoani i le mamanu faʻatatau o sui malosi ma filifilia fualaau faasaina. E le gata i lea, o lenei tuufaatasiga e mafai ona mafai ona faʻaaogaina i le atinaʻeina o prodrugs, lea e mafai ai ona filifili le vaega o le ethoxy, faʻamalolo le vailaʻau malosi i le nofoaga autu.Prodrugs e ofoina atu tulaga lelei e pei o le faʻaleleia atili o le solubility, faʻaleleia atili o le bioavailability, ma le tuʻuina atu o vailaʻau faʻapitoa, ma faʻamalosia ai le aoga o fualaau faasaina ma faʻaitiitia ai aʻafiaga. a'o le'i iloiloina le tuufaatasiga mo le atina'eina o falema'i.E taua tele lenei mea e faʻamautinoa ai lona saogalemu, aoga, ma le fetaui lelei mo togafitiga faʻapitoa. ose fa'aputuga tele fa'atasi ma fa'aoga fa'atatau i le matata o vaila'au.O lona fausaga tulaga ese ma mea tau vailaʻau e ofoina atu avanoa mo le suʻeina o vailaʻau, faʻamalosia, ma le atinaʻeina o vailaʻau.Peita'i, e mana'omia su'esu'ega fa'aopoopo ma su'ega e su'esu'e atoatoa ai lona malosi fa'afoma'i ma fa'amautinoa lona saogalemu mo le fa'aoga ile falema'i.