Oloa

RasGrf1 ma RasGrf2 o loʻo faʻatusatusa tele le faʻaogaina o le guanine nucleotide e mafai ona faʻagaoioia Ras poʻo Rho GTPases.O genes RasGrf e sili ona faʻaalia i totonu o le fatugalemu o le tino, e ui lava o faʻamatalaga patino o soʻo se nofoaga e mafai foi ona tupu i se isi mea.RasGrf1 ose faʻatama-faʻaalia, faʻamaufaʻailogaina e faʻaalia pe a uma ona fanau mai.I se faʻatusatusaga, RasGrf2 e leʻo lolomi ma faʻaalia se faʻamatalaga lautele lautele.O ituaiga eseese o isoforms mo kene e lua e mafai foi ona iloa i tulaga feavea'i eseese.O polotini RasGrf o loʻo faʻaalia fausaga faʻapitoa e fatuina e le tele o vaega e aofia ai le CDC25H ma le DHPH motifs e nafa ma le faʻalauiloaina o le GDP / GTP, i luga ole Ras poʻo Rho GTPase sini.O vaega eseese e taua tele e fa'amalamalama ai a latou gaioiga fa'atauva'a ma fa'avasega le fa'apitoa oa latou galuega fa'atino ina ia fa'afeso'ota'i fa'ailo eseese i luga o fa'ailoga i lalo ma tali telefoni feavea'i.E ui lava i la latou faʻataʻitaʻiga, RasGrf1 ma RasGrf2 faʻaalia tulaga faʻapitoa ma le le faʻaogaina o galuega faʻatino i le tele o faʻailoga faʻailoga e fesoʻotaʻi ma le tuputupu aʻe o le sela ma le eseesega faʻapea foʻi ma le faʻaogaina o le neuronal ma le tali poʻo le synaptic plasticity.E ui o RasGrfs uma e mafai ona faʻagaoioia e le glutamate receptors, G-protein-coupled receptors poʻo suiga i le intracellular calcium concentration, naʻo RasGrf1 ua lipotia mai e faʻagaoioia e le LPA, cAMP, poʻo le agonist-activated Trk ma cannabinoid receptors.O le suʻesuʻeina o faʻafitauli eseese o isumu tuʻituʻi ua faʻaalia ai se sao faʻapitoa a RasGrf1 i faʻagasologa o le manatua ma le aʻoaʻoina, photoreception, puleaina o le tuputupu aʻe o le post-natal ma le tele o le tino ma le pancreatic β-cell function ma glucose homeostasis.Mo RasGrf2, o matafaioi faʻapitoa i le faʻateleina o le lymphocyte, T-cell faʻailoga tali ma lymphomagenesis ua faʻamatalaina.