Oloa

O le histamine H4 receptor (HRH4), na maua i le 13 tausaga talu ai, ua manatu ose fuala'au fa'amoemoe e taula'i mo allergy, fulafula, autoimmune disorders ma le kanesa, e pei ona atagia mai i le fa'atupula'ia o le numera o lomiga fa'asaienisi ma talosaga pateni.E ui lava o le i ai o le HRH4 ua faʻamaonia i totonu o le suʻega, o lona nofoaga patino poʻo lana matafaioi e leʻi faʻamautuina.O iinei, na matou saili ai e faʻailoa le mafai ona aʻafia o HRH4 i le faʻatonutonuina o galuega a le Leydig cell.Na matou iloiloina muamua lona faʻaaliga i le MA-10 Leydig tumo sela ona iloilo lea o aʻafiaga o le lua HRH4 agonists i le steroidogenesis ma le faʻateleina.Na matou iloa o le HRH4 o loʻo faʻaalia i totonu o le MA-10 sela, ma o lona faʻagaoioia e taʻitaʻia ai le faʻasaina o le LH / tagata chorionic gonadotropin-induced cAMP production ma le faʻaaliga protein StAR.E le gata i lea, na matou matauina le faʻaitiitia o le faʻateleina o le cell pe a uma le 24-h HRH4 agonist togafitiga.Ona matou iloa lea mo nofoaga o le HRH4 faʻamatalaga i suʻega masani o isumu, ma maua ai le HRH4 immunostaining i le Leydig sela o isumu matutua 7-240 aso, ae o le 21-aso le matutua na faʻaalia foʻi le HRH4 faʻaaliga i tama tane.Mulimuli ane, na matou iloiloina le aʻafiaga o le HRH4 activation i luga o le faʻateleina o le tupuaga masani ma le le matutua o le rat Leydig cell culture, ma na faʻamaonia uma e aʻafia i le anti-proliferative aʻafiaga a HRH4 agonists.Ona o le taua o le histamine (2- (1H-imidazol-4-yl) etanamine) i le tagata (patho) physiology, o taumafaiga faʻaauau e faʻatonuina i le faʻamalamalamaina o meatotino faʻaalia o le HRH4 ma ona ligands.O lenei suʻesuʻega o loʻo faʻaalia ai nofoaga fou o le HRH4 faʻaaliga, ma e tatau ona mafaufau i le mamanu o agonists filifilia HRH4 mo togafitiga faʻapitoa.