Gentamycin Sulfate CAS:1405-41-0 Paʻepaʻe paʻepaʻe
| Numera Fa'amaumauga | XD90364 |
| Igoa Oloa | Gentamycin Sulfate |
| CAS | 1405-41-0 |
| Fuafua mole | C21H43N5O7H2So4 |
| Molecular Weight | 575.68 |
| Fa'amatalaga Teuina | 2 i le 8 °C |
| Fa'atonu Fa'asologa o Fa'asologa | 29419000 |
Fa'amatalaga o oloa
| Vai | 15% maualuga |
| pH | 3.5-5.5 |
| Su'ega | 590IU/mg min |
| Ta'amilosaga fa'apitoa | +107° i le +121° |
| Fa'aaliga | Pa'u pa'epa'e |
| Sulfate (SO4) | 32 - 35% |
| Lefulefu sulfated | <1.0% |
O manu'a tu'ufa'atasi e fa'alavelave e ala i le tuai ona leiloa o le oligodendrocytes, e mafua ai le fa'asolosolo fa'asolosolo o le demyelination.O le mea lea, o taʻiala faʻapipiʻi e tuʻuina atu ai sela o le oligodendrocyte laina ma faʻaleleia le lautele o le myelination e foliga mai e faʻamaonia mo le toe faʻaleleia o le vaʻai.O le suʻesuʻega o loʻo i ai nei na suʻesuʻeina pe faʻapipiʻiina o sela o le neural tagata (NSCs) faʻasolosolo faʻasolosolo e faʻaalia ai le Olig2 transcription factor, o se faʻatonuga taua o le atinaʻeina o le oligodendrocyte, e mafai ona faʻaleleia le toe faʻaleleia o le locomotor ma faʻaleleia le myelination i se faʻataʻitaʻiga manuʻa o manua.HB1.F3 (F3). ) laina NSC tagata ola pea na faʻaliliuina ma se retroviral vector encoding Olig2, o se faʻatonuga taua o le atinaʻeina o le oligodendrocyte.O le faʻaalia o Olig2 i tagata NSCs (F3.Olig2) faʻaosoina le faʻagaioiina o le NKX2.2 ma faʻatonuina le faʻavasegaina o NSCs i le oligodendrocyte lineage cell in vitro.Fa'atomuaga o Olig2 na tu'uina atu ai le maualuga o le fa'atupuina o gaioiga, ma o se numera tele atu o F3.Olig2 NSCs na maua i le 7 vaiaso talu ona fa'auluina i totonu o le va'aiga fa'alavelave nai lo matua F3 NSCs.F3.Olig2 NSCs na faʻaalia le femalagaiga faifaipea i le mea paʻepaʻe, ae o le F3 NSCs e tele lava na faʻatapulaʻaina i le mea efuefu poʻo faʻataʻamilomilo leona.O le tele o F3.Olig2 NSC o loʻo nofoia le mea paʻepaʻe faʻasao faʻavasegaina i oligodendrocytes matutua.O le fa'aliliuina o le F3.Olig2 NSCs na fa'ateleina ai le tele o mea pa'epa'e fa'asaoina ma fa'aitiitia ai le voluma.E le gata i lea, o le F3.Olig2 faʻapipiʻi na matua faʻateleina ai le mafiafia o le myelin faʻataʻamilo i axons i le mea papaʻe faʻasaoina.Mulimuli ane, o manu faʻatasi ma F3.Olig2 grafts na faʻaalia ai le faʻaleleia atili o le lelei o le hindlimbs locomotion.Transplantation o NSCs genetically modified e faʻavasegaina i se laina oligodendrocytic atonu o se fuafuaga lelei e faʻaleleia ai taunuʻuga o galuega pe a maeʻa le faʻalavelave faʻalavelave.O le su'esu'ega o lo'o i ai nei o lo'o fa'ailoa mai ai e mafai ona fa'aogaina mea mole mole e fa'atonutonu ai fa'ai'uga o fa'ai'uga e fa'aleleia atili ai le toe fa'aleleia o togafitiga fa'avae.
