Oloa

O auala mole mole faʻamaʻi i faʻamaʻi ate cirrhotic e pei ole hepatitis C virus (HCV), autoimmune hepatitis (AIH) ma le biliary cirrhosis muamua (PBC) e le lelei ona faʻaalia.O kenera fa'aalia eseese e masani ona taua i le pathogenesis o fa'ama'i.Supression subtractive hybridization (SSH) o se genome-lautele auala e faʻatamaoaigaina mo faʻamatalaga eseese mRNA transcripts.Matou te faʻamoemoe e faia ni suʻesuʻega fou o faʻamatalaga o kenera eseese i le cirrhosis e faʻaaoga ai le SSH faʻatasi ma le faʻatusatusaina o le faʻasologa o le transcriptase polymerase chain reaction (RT-PCR).O fa'aliliuga o le ate ile HCV cirrhosis, AIH cirrhosis, PBC, ma le ate e le'i fa'ama'i sa su'esu'eina e le SSH.Na toe su'esu'e fa'ailoga fa'apitoa e fa'atatau i le fa'avasegaina o le dot-blot ma fa'asologa.O fa'amatalaga o kenera filifilia na fa'atatauina ile RT-PCR taimi moni.I le mae'a ai o le SSH, 694 clones na toe su'eina mo fa'aaliga kenera eseese, lea e 145 na fa'asologa ma maua mai e 89 kenera eseese.E fitu clones na'o fa'atasi ma fa'asologa fa'asologa fa'asologa (EST) fa'asologa fa'asologa o kenera e leai se aoga.O faʻamatalaga faʻatulafonoina o kenera e fa na faʻamaonia e le RT-PCR taimi moni: transmembrane 4 superfamily sui 3 (tetraspanin CO-029) i ituaiga uma o le cirrhosis, hedgehog interacting protein (HIP) i AIH cirrhosis ma chitinase 3-like-1 (HC gp-39 poʻo le ykl-40) ma le arginine-glutamic acid toe fai (RERE) ile HCV cirrhosis.RERE gene polymorphisms ma splice variants na matauina i mea uma na suʻesuʻeina.Tetraspanin CO-029 fa'atulafonoina maualuga na fa'atatau i sela ductular sela.I le fa'ai'uga, o fa'amatalaga fou o fa'amatalaga fa'a-fa'a'ese'esega i le cirrhosis o le tagata na faia e fa'aaoga ai le SSH e fai ma mea faigaluega muamua.Aemaise lava, o nisi su'esu'ega o le ga'o RERE ma ana oloa i fa'ama'i ate e feso'ota'i ma le HCV e mana'omia.