Oloa

Togafitiga o sela mamame ma vailaʻau chemotherapeutic e mafai ona iʻu ai i faʻalavelave o vaituloto nucleotide.O le mata'ituina o nei fa'alavelave i sela tumo fa'aleaganu'u mai fa'apogai a tagata e aoga mo le su'esu'eina o le a'afiaga o vaila'au fa'asaina ma le malamalama atili i le faiga o gaioiga o nei vaila'au.I lenei suʻesuʻega, e tolu vasega o vailaʻau chemotherapeutic faʻatasi ai ma auala eseese o gaioiga na faʻaaogaina i le atinaʻeina o faʻataʻitaʻiga o vailaʻau faʻasolosolo.O le LC-faʻatatau i metabolomics suʻesuʻega o nucleotides i sela o le kulupu faʻatonutonu ma le vailaʻau-togafitiga vaega na faia.Na tu'ufa'atasia le tele o metotia o fa'amaumauga mo le fa'ailoaina o fa'ailoga olaola e mafai ona feso'ota'i ma fa'agaioiga o vaila'au, e aofia ai su'esu'ega tasi-auala o feeseesea'iga, su'esu'ega vaega autu, ma le fa'aogaina o pupuni uiga.O le mea e ofo ai, o sela tumo o le vaega e pulea uma ma vaega e togafitia fualaau faasaina e mafai ona iloga mai le tasi ma le isi, ma e tele fesuiaiga na iloa o ni biomarkers potentia, e pei o le ATP, GMP, ma le UDP mo sui antimetabolite, ATP, GMP, ma CTP. mo DNA-faʻaleagaina sui, faʻapea foʻi ma le GMP, ATP, UDP, ma le GDP mo le mitotic spindle agents.O isi fa'amaoniga o fa'ailoga fa'apitoa na fa'atinoina i le fa'aogaina o le fa'aogaina o le fa'aogaina o le fa'aogaina.Mafaufau i la latou vaega tutusa i lalo o le pupuni, lea e sili atu nai lo le 0.9, e mafai ona faʻauʻuina o le GMP ma le ATP o le biomarkers sili ona lelei mo vailaʻau faʻaleagaina DNA, faʻapea foʻi ma le GMP, ATP, ma le UDP mo isi vasega e lua o vailaʻau.O lenei faʻatapulaʻaina o le nucleotide e le mafai ona faʻamalamalamaina atoatoa le faiga o vailaʻau e iva, ae o loʻo tuʻuina atu ai faʻamaoniga muamua mo le matafaioi a le pharmacometabolomics i le atinaʻeina muamua o vailaʻau a itiiti mai.