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Oloa

beta-Nicotinamide adenine dinucleotide trihydrate Cas: 53-84-9 95% Pa'epa'e pa'epa'e

Fa'amatalaga Puupuu:

Numera fa'amaumauga: XD0433
Cas: 53-84-9
Fuafua mole: C21H27N7O14P2
Molecular Weight: 663.43
Avanoa: E tele
Tau:  
mua'i afifi: 1g USD10
Vaega Tele: Talosaga Sesii

 

 

 

 

 


Fa'amatalaga Oloa

Faailoga o oloa

Numera Fa'amaumauga XD90433
Igoa Oloa beta-Nicotinamide adenine dinucleotide trihydrate

CAS

53-84-9

Fuafua mole

C21H27N7O14P2

Molecular Weight

663.43

 

Fa'amatalaga o oloa

Vai maualuga 8.0%
Metala mamafa maualuga 20ppm
Fa'aaliga Pa'u pa'epa'e
Su'ega 99%

 

Niacin (nicotinic acid) e avea o se monotherapy e mafai ona faʻaitiitia ai le lamatiaga o faʻamaʻi toto, ae o lona faiga o gaioiga e tumau pea fefinauai, ma atonu e le faʻalagolago i le faʻaogaina o le lipid faʻaogaina o aʻafiaga.Niacin talu ai nei na faʻaalia e faʻaleleia ai le galuega endothelial ma le toe faʻafouina o le vascular, e tutoatasi mai le faʻasaʻoina o le dyslipidemia, i faʻataʻitaʻiga o rodent o manuʻa vascular ma maʻi gasegase.I le avea ai o se mea e mafai ona maua mai i le biosynthetic precursor mo NAD(+), e mafai e le niacin ona maua nei penefiti vascular e ala i tali NAD(+)-faalagolago, sirtuin (SIRT).I le isi itu, e mafai e le niacin ona galue e ala i lona faʻafeiloaʻi, GPR109A, e faʻaleleia ai le gaioiga o le endothelial, e ui lava e le o iloa e le endothelial sela e faʻaalia ai lenei tali.Na matou manatu o le niacin e faʻaleleia saʻo le gaioiga o le endothelial cell i le taimi o le faʻaalia i tulaga o le lipotoxic ma saili e fuafua le mea e ono mafai ona aʻafia. e maualalo le maualuga o le niacin (10 μM), poʻo le nicotinamide mononucleotide (NMN) (1 μM), o se NAD (+) tuusaʻo muamua.E ui lava ina faʻaleleia uma e le niacin ma le NMN le faʻaogaina o le HMVEC tube i le taimi o le mamafa o palmitate, ae naʻo le NMN na faʻateleina le telefoni NAD (+) ma le SIRT1 gaioiga.Na matou matauina atili o le HMVEC faʻaalia GRP109A.O le faʻagaoioia o lenei tali faʻatasi ma le acifran poʻo le MK-1903 toe faʻaleleia le faʻaleleia o le niacin i le faʻavaeina o le tube HMVEC, aʻo le GPR109A siRNA faʻaitiitia le aʻafiaga o le niacin.Niacin, i se faʻaititia, faʻaleleia le HMVEC angiogenic galuega i lalo ole lipotoxic tulaga, atonu e tutoatasi mai le NAD( +) biosynthesis ma le SIRT1 faʻagaoioia, ae e ala i le faʻagaioiina o le tali atu o le niacin.


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    beta-Nicotinamide adenine dinucleotide trihydrate Cas: 53-84-9 95% Pa'epa'e pa'epa'e