Oloa

O le 4-Chlorophenylboronic acid ose mea fa'aola e maua ai le tele o fa'aoga i vaega eseese, e aofia ai le fa'aogaina o meaola, vaila'au kemisi, ma mea fa'asaienisi.E aofia ai se mama phenyl e suitulaga i se chloro group (-Cl) ma se boronic acid group (-B(OH) 2). O se tasi o faʻaoga muamua o le 4-Chlorophenylboronic acid o lana matafaioi o se reagent taua i le palladium-catalyzed. fa'afeso'ota'i feso'ota'iga, e pei o Suzuki-Miyaura ma Heck tali.O nei gaioiga e aofia ai le faʻavaeina o fusi carbon-carbon, lea e galue ai le 4-Chlorophenylboronic acid o se puna boron e mafai ona faʻapipiʻiina ma electrophiles eseese, pei ole aryl poʻo vinyl halides.O lenei mea e mafai ai ona tu'ufa'atasiga o mea fa'aola eseese, e aofia ai vaila'au, vaila'au fa'ato'aga, ma mea e fa'aopoopoina ai.Mo se fa'ata'ita'iga, e mafai ona o'o iai ni fa'amination reactions e fai ai le 4-chloro-phenylboronates, lea e mafai ona avea ma mea fa'aoga tulu'i mo le tu'ufa'atasiga o fa'aputuga eseese o lo'o iai le nitrogen.O lenei vaega fa'atinoga fa'apitoa e fa'aleleia ai le fa'aogaina o le 4-Chlorophenylboronic acid, fa'atagaina mo le fa'atupuina o molela'au lavelave ma mea fa'apitoa.O le isi fa'aoga taua o le 4-Chlorophenylboronic acid o lo'o taoto i vaila'au kemisi.Ua fa'aalia le folafolaga o se pharmacophore po'o se poloka faufale mo le atina'eina o mea olaola.Ona o le vaega o le boronate, e mafai ai e le 4-Chlorophenylboronic acid ona fausia ni fusi faʻafesoʻotaʻi e mafai ona fesuiaʻi ma mole o loʻo iai le diol, e pei o gaʻo ma nucleotides.O lenei fesoʻotaʻiga ua faʻaaogaina e mamanu ai le iniseti o le enzyme, ligands receptor, ma isi vailaʻau vailaʻau.Mo se faʻataʻitaʻiga, o le iniseti proteasome faʻavae boronic acid ua atiae mo le togafitia o le tele o myeloma. I le fanua o mea faasaienisi, 4-Chlorophenylboronic acid ua maua le faʻaogaina i le fesuiaiga o luga poʻo le faʻaogaina o mea aoga.E ala i le fa'aogaina o le boronic acid group, e mafai ona fausia ai ni fa'alavelave toe fa'afo'i malosi ma polyols po'o le hydroxyl-containing compounds.O lenei mea totino e mafai ona faʻaaogaina mo le faʻaogaina o luga, e pei o le fausiaina o faʻauluulu faʻamalosi poʻo le saunia o masini mo le suʻeina o gaʻo poʻo isi analytes. , ma meafaitino faasaienisi.O lona fa'agaioiga i le fa'avaeina o fusi kaponi-carbon, agava'a mo le fa'aofiina o vaega fa'atino, ma le mafaia ona fa'atupu fa'amaufa'ailoga e mafai ona toe fa'afo'isia e avea ai ma meafaigaluega taua mo tagata su'esu'e i matata fa'asaienisi eseese.