4-Aminophthalhydrazide AMPPD Cas:3682-14-2 Samasama mumu i le amber i le paʻu lanumeamata pogisa i le paʻu.
| Numera Fa'amaumauga | XD90156 |
| Igoa Oloa | 4-Aminophthalhydrazide |
| CAS | 3682-14-2 |
| Fuafua mole | C8H7N3O2 |
| Molecular Weight | 177.16 |
| Fa'amatalaga Teuina | Faleoloa ile RT |
Fa'amatalaga o oloa
| Fa'aaliga | Samasama mumu i le amber i le lanumeamata lanumeamata paʻu i luga |
| Asay | ≥98.0% |
| Malosi | 1.433 |
| Liu liusuavai | 300ºC |
| Fa'apuna | 633°C ile 760 mmHg |
| Fa'ailoga moli | 336.7°C |
| Solubility | Solu i le ammonium hydroxide, sodium carbonate poʻo isi faʻavae. |
1.We suʻesuʻeina ma faʻatusatusa le aʻafiaga o le lima H1-antihistamines i luga o le faʻamalosia o le faʻamaʻiina o le faʻamaʻiina i le faʻaopoopoga ma le intracellular maualuga o leukocytes polymorphonuclear tuʻufaʻatasia ma faʻaosofia tagata. Oxidative paʻu o neutrophils tagata vavae ese na suʻesuʻeina e ala i le luminol ma isoluminol faʻaleleia chemiluminescence. fa'asologa o le malosi mo H1-antihistamines e fa'aitiitia ai le chemiluminescence na iloiloina extracellularly: dithiaden> loratadine> chlorpheniramine> brompheniramine> pheniramine ma i le nofoaga intracellular: loratadine> dithiaden.H1-antihistamines e matua ese lava e tusa ai ma lo latou fausaga faʻamaʻi i le taofiofia uma o le oxidative burs. - ma le nofoaga intracellular o tu'ufua fa'aosofia tagata neutrophils.
2.Chemiluminescence faiga faʻaleleia e soʻo se isoluminol poʻo luminol faʻatasi ma se peroxidase o auala maʻaleʻale ia mo le suʻesuʻeina o ituaiga o okesene reactive (ROS) e gaosia e le phagocyte NADPH oxidase.O mea faʻapipiʻi e lua e tutusa lelei le faʻatulagaina, e ese naʻo le tulaga o le vaega amino i le mama manogi o mole.O lenei eseesega e maua ai le isoluminol o se mole mole lipophilic e itiiti ifo le faʻaogaina i paʻu olaola.O le faʻaaogaina o le isoluminol e faʻatapulaʻaina i suʻesuʻega e faʻatatau i le faʻaogaina o metabolites okesene.I lenei suʻesuʻega matou te faʻaalia ai o peptides synthetic e maua mai i le N-terminal domain o le calcium-regulated protein annexin AI faʻalavelave i le mauaina o radicals i se isoluminol-amplified, ae le o se luminol-amplified, system.O peptides e maua mai AI e faʻaitiitia ai le malamalama ma le isoluminol faʻafiafiaina e le superoxide ma le horseradish peroxidase (HRP) i le formyl-methionyl-leucyl-phenylalanine- ma le phorbol my ristate acetate-stimulated sela, faʻapea foʻi ma le hydrogen peroxide ma le HRP.E le o iloa le faiga sa'o mo le taofia.O fa'ai'uga o lo'o tu'uina mai e fa'ailoa malosi mai ai o le fa'aitiitiga o le tali fa'a-telefoni ua maua i le isoluminol-amplified chemiluminescence e tatau ona fa'amaonia i se isi auala e fuafua ai le fa'asa'olotoina o anion superoxide ma le hydrogen peroxide.
