Oloa

(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, ua lauiloa foi o le TBDMS-puipuia tetrahydro-2H-pyran -2-tasi, o se tuufaatasiga e masani ona faʻaaogaina i le faʻaogaina o meaola ma o se vaega puipuia i le fanua o kemisi.O se tasi o faʻaoga taua o le TBDMS-puipuia-tetrahydro-2H-pyran-2-one o lona faʻaogaina o se poloka fale i le faʻasologa. o molelaʻau faʻaola lavelave.O lo'o iai le tele o nofoaga fa'afoliga e mafai ona o'o iai suiga eseese o vaega fa'atino.O le vaega puipuia o le TBDMS (tert-butyldimethylsilyl) o loʻo iai i totonu o le mole e maua ai le mautu ma faʻatagaina mo suiga filifilia o vaega faʻapitoa.O lenei agavaʻa e faʻaogaina ai le tetrahydro-2H-pyran-2-one e puipuia le TBDMS o se mea taua tele i le tuʻufaʻatasia o oloa faʻanatura, vailaʻau, ma isi vailaʻau lelei. matafaioi o se vaega puipuia mo ava malosi ma amine i le faʻaogaina o meaola.O le vaega TBDMS e mafai ona fa'aopoopoina fa'aopoopo i vaega hydroxyl po'o amino, e fa'amama lelei i latou i taimi eseese o la'asaga tali.O lenei puipuiga e puipuia ai itu e le mana'omia-gaoioiga ma mautinoa o suiga mana'omia e tupu i nofoaga e mana'omia.O le taimi lava e maeʻa ai tali manaʻomia, e mafai ona faigofie ona aveese le vaega o le TBDMS, faʻaalia le uluai hydroxyl poʻo le amino vaega e aunoa ma le afaina ai o isi galuega i totonu o le mole. carbohydrates.E mafai ai mo le puipuiga filifilia o vaega hydroxyl i mole suka i le taimi o le glycosylation reactions, e mafai ai ona faʻapipiʻiina o glycans lavelave ma glycosides.O lenei taʻiala puipuia e taua tele i kemisi carbohydrate, lea e tele vaega hydroxyl o loʻo i ai ma e manaʻomia le regioselectivity faʻapitoa. E le gata i lea, o le TBDMS-protected tetrahydro-2H-pyran-2-one o loʻo faʻaaogaina i le sauniuniga o polymers functionalized.O le tuufaatasiga e mafai ona tuʻufaʻatasia i totonu o fausaga polymer, tuʻuina atu nofoaga faʻafefe mo nisi suiga ma faʻafesoʻotaʻi tali.O lenei mea e mafai ai ona fatuina mea polymer ma faʻaogaina mea totino ma faʻatinoga, e pei o le faʻaleleia atili o le mautu, biocompatibility, ma le faʻasaʻoina o fualaau faasaina. I le faaiuga, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6 -((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, poʻo le TBDMS-puipuia tetrahydro-2H-pyran-2-one, o se faʻalapotopotoga faʻapitoa ma faʻaoga eseese i le faʻaogaina o meaola, aemaise lava o se poloka fale ma vaega puipuia. .O lona gafatia e filifili le puipuia o vaega galue ma faafaigofie suiga lavelave mole e avea ma meafaigaluega taua i le matata o le kemisi.Fa'aauau su'esu'ega ma su'esu'ega o ana talosaga e ono fa'ailoa atili ai fa'aoga ma saofagā i le alualu i luma i le kemisi fa'akomepiuta ma mea fa'asaienisi.