E lua isomeric bicyclo[4.1.0]heptane analogues o le glycosidase inhibitor galacto-validamine, (1R*,2S,3S,4S,5S,6S*)-5-amino-1-(hydroxymethyl)bicyclo[4.1.0]heptane -2,3,4-triol, ua faʻapipiʻiina i 13 laasaga mai le 2,3,4,6-tetra-O-benzyl-D-galactose.O gaoioiga fa'alavelave a amine fa'asaina e lua, ma a latou acetamides tutusa, na fuaina e fa'atatau i enzymes alpha-galactosidase faapisinisi mai le kofe ma le E. coli.O le gaioiga o le glycosyl hydrolase family GH27 enzyme (kofe pi) na faʻatauvaʻa faʻatauvaʻa e le 1R,6S-amine (7), o se fegalegaleaiga faʻatasi na faʻaalia e le K (i) tau o le 0.541 microM.O le GH36 E. coli alpha-galactosidase na faʻaalia se fesoʻotaʻiga vavalalata sili atu ona vaivai ma le 1R,6S-amine (IC (50) = 80 microM).O le diastereomeric 1S,6R-amine (9) ua fusifusia vaivai i galactosidases e lua, (kofe pi, IC(50)= 286 microM) ma (E. coli, IC(50)= 2.46 mM).
