Oloa

Trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid ose vailaʻau faʻapipiʻi ma faʻaoga eseese, aemaise i le faʻaogaina o meaola ma suʻesuʻega vailaʻau.O lona fausaga e aofia ai se mama pyrrolidine e suitulaga i se vaega amino ma se tert-butoxycarbonyl (Boc) vaega puipuia i luga o le nitrogen atom.Ose tasi o le faaaogaina muamua o trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3- o le carboxylic acid o se poloka faufale i le tu'ufa'atasiga o molela'au lavelave.O le i ai o le vaega amino e mafai ai mo le tele o suiga o vailaʻau, e aofia ai le amidation, acylation, poʻo le faʻapipiʻiina o tali, lea e totonugalemu i le fatuina o mea eseese ma vailaʻau faʻapitoa poʻo vailaʻau.O le vaega puipuia o le Boc e puipuia le vaega amino i le taimi o nei gaioiga, e puipuia ai fegalegaleaiga e le manaʻomia poʻo faʻalavelave itu. fualaau faasaina.Peptides o filifili pupuu o amino acids o loʻo iai sona sao taua i gaioiga faʻaola.E ala i le faʻamalo filifilia o le vaega o le Boc, e mafai e le faʻapipiʻi ona avea o se amino acid building block e fausia ai peptide sequences.O lenei mea e mafai ai mo le fausiaina o vailaʻau faʻavae peptide, lea e mafai ona faʻatatau i sini mole mole, e pei ole talitali poʻo enzymes, ma faʻaogaina auala olaola eseese.O nei vailaʻau ua faʻaalia le folafolaga i vaega e pei o togafitiga o le kanesa, togafitiga faʻamaʻi faʻamaʻi, ma faʻafitauli o le hormonal. O le faʻaogaina o le tuʻufaʻatasiga e faʻalautele atu foi i lona gafatia e avea o se mea amata mo le faʻapipiʻiina o molelaʻau faʻasolosolo laiti ma gaioiga olaola.E ala i le faʻaogaina o vaega faʻatino ma le stereochemistry o le trans-4-Amino-1-(tert-butoxycarbonyl) pyrrolidine-3-carboxylic acid, e mafai e tagata suʻesuʻe ona fatuina analogs poʻo mea e maua mai ma faʻaleleia mea tau vailaʻau.E mafai ona suʻesuʻeina nei mea faʻapipiʻi faʻapitoa mo fualaau faʻatau, iloilo mo lo latou gafatia e fegalegaleai ma faʻamoemoega o meaola, pe suʻesuʻeina mo a latou mea faʻainisinia. E le gata i lea, trans-4-Amino-1-(tert-butoxycarbonyl) pyrrolidine-3-carboxylic acid e mafai fa'aaoga e fai ma fa'aputuga fa'asino mo fa'amoemoega au'ili'ili.O lona fausaga faʻamautu ma mea faʻapitoa e faʻamaonia e taua tele e avea o se tulaga faʻatonutonu lelei i le gaosiga o vailaʻau, faʻamautinoaina le saʻo ma le faʻamaoni o metotia auʻiliʻili e faʻaaogaina e iloilo ai le mama ma le malosi o mea faʻapipiʻi fesoʻotaʻi. I le faaiuga, trans-4-Amino-1- (tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid ose fa'aogaina tele ma fa'aoga taua i le fa'aogaina o meaola ma su'esu'ega vaila'au.O lona amino acid-pei o le fausaga ma le vaega puipuia e avea o se poloka faufale taua mo le fausiaina o molelaʻau faʻapitoa faʻapitoa, e aofia ai peptides ma sui o fualaau faasaina.O su'esu'ega fa'aauau i ana meatotino ma suiga o le a fa'aauau pea ona fa'alauteleina ana talosaga ma fesoasoani i le atina'eina o ni vaila'au fa'afoma'i fou.