Oloa

O le tuufaatasiga tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2, 2-dimethyl-1,3-dioxane-4-acetate o se faʻalapotopotoga faʻapitoa faʻapipiʻi faʻatasi ma faʻaoga talafeagai i vaega eseese e aofia ai vailaʻau, agrochemicals, ma mea kemisi. pyrimidine, ma se mama dioxane.O le i ai o vaega tert-butyl ma acetate e taʻu mai ai le mautu ma le faigofie o le faʻaogaina.O le i ai o le vaega o le pyrimidine o loʻo fautua mai ai le mafai ona fegalegaleai ma faʻamoemoega o meaola, ma avea ai ma sui taua mo le suʻeina o vailaʻau.E mafai ona fa'aleleia atili ai le gaioioiga olaola po'o le filifilia o le sini. O le vaega o le ethenyl o lo'o i totonu o le fa'alapotopotoga e fa'aalia ai le fa'aopoopoina o le fa'avasegaga, lea e mafai ona aoga mo le fa'aogaina o le malosi, aoga, ma mea tau vailaau.O mea e suitulaga i le vaega o le ethenyl, e pei o le methyl ma le methylsulfonyl amino vaega, e faʻaleleia atili ai le vailaʻau o vailaʻau ma e mafai ona saofagā i lona bioactivity poʻo mea e pei o fualaau faasaina. , e aofia ai le avea o se solubility enhancer po'o se faiga e tu'uina atu mo isi mea fa'amalositino.O lona i ai i totonu o lenei fa'aputuga e ta'u mai ai e mafai ona fa'aleleia atili ai le solubility po'o le mautu o le fa'aputuga. E ese mai i vaila'au fa'aoga, e mafai fo'i e lenei fa'aoga ona maua ni fa'aoga i vaila'au fa'ato'aga e fai ma sui o le puipuiga o fua.E ono mafai ona fa'aalia gaioiga fa'ama'i fa'ama'i fa'ama'i fa'ama'i pe iai fo'i isi a'afiaga i le tuputupu a'e ma le soifua maloloina o la'au.E mafai ona avea o se poloka faufale poʻo se faʻamuamua mo le tuʻufaʻatasia o mea fou e iai mea faʻapitoa, e pei o mea polymeric poʻo vailaʻau faʻapitoa. I le aotelega, tert-Butyl 6-[(1E) -2-[4-(4-fluorophenyl) -6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate o se faʻapipiʻi faʻatasi ma faʻaoga talafeagai i vailaʻau, fa'ato'aga, ma mea kemisi.O lona fausaga fa'alekemiki fa'apitoa ma vaega fa'atino e fa'ailoa mai ai le talafeagai mo le atina'eina o vaila'au, puipuiga o fuala'au, po'o le tu'ufa'atasiga o mea fou.Ae ui i lea, o nisi suʻesuʻega e manaʻomia e suʻesuʻe atoatoa ai lona bioactivity, faʻatonuga filifilia, pharmacokinetic meatotino, ma le saogalemu aʻo leʻi mafai ona faʻaaogaina i faʻaoga faʻapitoa.