Oloa

Tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino) pyridin-3-yl) piperazine-1-carboxylate o se tuufaatasiga ma le gafatia tele i vailaʻau kemisi ma le atinaʻeina o vailaʻau.O lona fausaga mole lavelave o loʻo fautua mai ai le tele o faʻaoga faʻapitoa. O lenei tuufaatasiga o loʻo i ai se piperazine-1-carboxylate core, o se faʻataʻitaʻiga masani ona faʻaaogaina i vailaʻau kemisi ona o lona natura faʻapitoa ma le tele o mea e mafai ona faʻatatau i fualaau.O le i ai o le piperazine moiety e mafai ai ona fegalegaleai ma faʻafeiloaʻi eseese ma enzymes, ma avea ai ma sui fiafia mo le atinaʻeina o vailaʻau faʻamaʻi. O le 6- (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido [2,3-d] pyrimidin-2-yl vaega i totonu o le fausaga e maua ai le gaioiga o vailaʻau.O ia pyrido [2,3-d] pyrimidine derivatives ua suʻesuʻeina tele mo a latou mea faʻamaʻi, antiviral, ma anticancer.O le cyclopentyl ma le methyl vaega e saofagā i le lipophilicity o le tuufaatasiga, lea e mafai ona faʻaleleia ai lona faʻaogaina o le telefoni feaveaʻi ma le bioavailability.O le tert-butyl ester group e maua ai le mautu i le tuufaatasiga ma e mafai ona faigofie ona liua i isi vaega o galuega, e mafai ai ona toe faʻaleleia atili poʻo faʻasologa.O lenei fetuutuunai e taua tele i vailaʻau kemisi, aua e mafai ai ona atinaʻe le sili atu le malosi ma le filifilia o mea faʻapipiʻi.O loʻo faʻaalia ai e mafai e le faʻapipiʻi ona i ai se aʻafiaga i auala faʻailoga intracellular ma e mafai ona suʻesuʻeina atili mo lona gafatia e avea o se modulator poʻo se faʻafeagai o faʻamaʻi faʻapitoa e aʻafia i faʻamaʻi tulaga. (1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl) piperazine-1-carboxylate fa'amanino lona gafatia i le atina'eina o togafitiga fou.E ofoina atu avanoa e suʻesuʻe ai le enzyme inhibition, receptor binding, ma le faʻaogaina o meaola eseese.O ona foliga faʻapitoa faʻapitoa ma gaioiga faʻapitoa e mafai ona avea ma mea manaia mo suʻesuʻega atili ma atinaʻe i le matata o vailaʻau kemisi. 5-methyl-7-oxo-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate o loʻo umia le folafolaga e avea o se tuufaatasiga tele mo le atinaʻeina o fualaau faasaina.O lona fausaga lavelave ma galuega fa'afoma'i e ono mafai ona avea ma sui fa'afiafia mo su'esu'ega atili e avea o se vaila'au fa'apitoa mo fa'ama'i ma tulaga eseese.