Oloa

T-Butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate o se vailaʻau vailaʻau faʻatasi ai ma se fausaga faʻalavelave e masani ona faʻaaogaina i le faʻaogaina o meaola ma o se vaega puipuia i kemisi carbohydrate.E lauiloa mo lona mafaia lelei ona puipuia vaega hydroxyl ma puipuia tali e le manaʻomia i le taimi o suiga faʻainisinia eseese.O se tasi o faʻaoga muamua o le T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5- dihydroxyhexanoate o loʻo i totonu o le tuʻufaʻatasiga o mea faʻapipiʻi lavelave.O vaega o le Hydroxyl e matua'i fa'agaoioia ma e mafai ona o'o i ni fa'alavelave le mana'omia i le taimi o suiga fa'a vaila'au.E ala i le filifilia o le puipuia o nei vaega i le T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate moiety, e mafai e chemists ona pulea gaioiga ma maua ai mea e manaʻomia.A maeʻa le suiga o vailaʻau manaʻomia, e mafai ona faigofie ona aveese le vaega puipuia, faʻatagaina mo le toe faʻaleleia o vaega muamua o le hydroxyl. I le kemisi carbohydrate, T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate e masani ona faʻaaogaina mo le puipuia o mole mole suka.Sugars e tele vaega hydroxyl e mafai ona tali atu i reagents, e oʻo atu ai i mea e le manaʻomia.E ala i le filifilia o le puipuia o nei vaega hydroxyl ma T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate, e mafai e chemists ona faʻaogaina vaega o totoe o le hydroxyl e aunoa ma le faʻalavelave.O lenei mea e mafai ai mo le tuʻufaʻatasia o mea faʻapitoa suka suka ma suʻesuʻega o fegalegaleaiga carbohydrate-protein poʻo le faʻaogaina o glycoconjugates. E le gata i lea, o le T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5- dihydroxyhexanoate vaega puipuia e masani ona faʻaaogaina i le taimi o le tuʻufaʻatasia o mea faʻalenatura, vailaʻau, ma isi mea faʻapitoa faʻapitoa.O lona puipuiga lelei ma le puipuia o meatotino e mafai ai e kemisi ona maua le tele o ituaiga mole mole eseese.O le puipuiga o vaega hydroxyl faʻapitoa e fesoasoani i le faʻatonutonuina o auala faʻaalia ma le ausiaina o le regioselectivity poʻo le stereoselectivity manaʻomia. I le faaiuga, T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate o se fa'aputuga tele fa'aoga lautele i kemisi fa'akomepiuta fa'akomepiuta, aemaise i le puipuiga ma le deprotection o vaega hydroxyl.O lona fausaga tulaga ese e mafai ai mo le puipuiga filifilia, e mafai ai e chemists ona pulea gaioiga ma maua mai oloa manaʻomia.O ana fa'aoga e amata mai i le tu'ufa'atasiga o mea fa'aola lavelave i le kemisi ga'o ma le gaosiga o oloa fa'anatura ma vaila'au.O le malosi o le fa'aogaina e puipuia ai vaega hydroxyl lelei e avea ai ma meafaigaluega taua i vaega eseese o su'esu'ega ma atina'e kemikolo.