Oloa

Flow cytometry o se auala faʻamoemoe mo le faʻatinoina o suʻesuʻega faʻamaʻi faʻamaʻi i vitro ma faʻateleina le gafatia mo le faʻaogaina i nofoaga o fanua.Na matou suʻesuʻeina in vitro susceptibility i vailaʻau faʻamaʻi e fitu mo le 40 fou P. falciparum fanua faʻaesea e ala i le faʻaogaina o le cytometry method (FCM), o le colorimetric LDH-based ELISA: DELI), ma le suʻesuʻega faʻataʻitaʻiga faʻataʻitaʻi microscopic o le tuputupu aʻe.Mo FCM, 184/280 (66%) fa'ata'ita'iga na fa'amalieina tu'utu'uga o le taliaina, fa'atusatusa ile 166/280 (59%) mo DELI.Sa i ai se maliliega lelei i le va o le FCM ma le microscopy, ae o le DELI na faʻatupulaia le maualuga o le afa-maximal inhibition constants (IC50s) nai lo le FCM, faʻatasi ai ma le faʻaituau atoa o le 2.2-fold (Bland-Altman faʻatusatusaga).O mea taua mo le artesunate ma le dihydroartemisinin na sili ona afaina.O faʻalavelave faʻafuaseʻi i faʻailoga i maualuga maualuga o le mefloquine ma faʻalapotopotoga faʻapitoa na sili atu ona faʻailogaina i le suʻega DELI, faʻapea o aʻafiaga i luga o le LDH e mafai ona nafa.O le leiloa o le FCM faʻailoga ona o le toe osofaʻia poʻo le faʻagesegese o le tuputupu aʻe na matauina i se numera itiiti o faʻataʻitaʻiga.O nei fa'ai'uga ua fa'alautele ai galuega muamua ile fa'aogaina ole flow cytometry e fa'amautu ai le fa'ama'i fa'ama'i ile tulaga ole numera o fa'ata'ita'iga, ituaiga o vaila'au, ma fa'atusatusa i isi metotia.