Oloa

(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)methanone, e taʻua foi o le CF3-112, o se vailaʻau vailaʻau ma le tele o faʻaoga taua i le matata o vailaʻau kemisi ma vailaʻau. atinaʻe.O se tasi o faʻaoga tele o le CF3-112 o se inhibitor kinase.Kinases o enzymes e faʻatonutonuina le tele o gaioiga feaveaʻi i totonu o le tino, e aofia ai le tuputupu aʻe o sela, vaevaega, ma fesoʻotaʻiga.Dysregulation of kinases e masani ona fesoʻotaʻi ma faʻamaʻi e pei o le kanesa ma faʻafitauli autoimmune.CF3-112 ua maua e faʻaalia ai le malosi o le faʻalavelave faʻasaga i nisi kinases, ma avea ai ma sui tauva mo le atinaʻeina o togafitiga faʻatatau. Aemaise lava, CF3-112 ua faʻaalia le faʻaogaina o le Aurora kinases, lea e taua tele i le vaevaeina o sela ma e soona fa'ailoa soo i sela o le kanesa.E ala i le filifilia ma le taofiofia o nei kinases, e mafai e le CF3-112 ona fesoasoani e taofi le vave faʻateleina o sela o le kanesa ma e mafai ona maua ai se faʻamanuiaga faʻapitoa. fa'ama'i fa'ama'i e pei o le ma'i leukemia myeloid (AML) ma neoplasms myeloproliferative.O le taofiofia o nei kinases ma le CF3-112 e mafai ona faʻalavelaveina ala faʻailoga e faʻaosoina ai le tuputupu aʻe ma le ola o sela o le kanesa, e ofoina atu avanoa fou mo togafitiga o nei faʻamaʻi. -a'afiaga inflammatory.O le fulafula o se tali faʻalavelave faʻapitoa e taʻalo i le tele o faʻamaʻi, e aofia ai faʻafitauli o le autoimmune ma tulaga faʻamaʻi masani.CF3-112 ua faʻaalia le folafolaga o se faʻalavelave o nisi o auala faʻafefe, e mafai ona ofoina atu se togafitiga faʻapitoa mo le puleaina o nei tulaga. E ui o le CF3-112 o loʻo umia le gafatia tele, e taua le matauina o nisi suʻesuʻega ma atinaʻe e manaʻomia ina ia malamalama atoatoa i lona aoga, saogalemu. faʻamatalaga, ma le faʻaoga sili ona lelei.E pei o soʻo se mea faʻapipiʻi, e manaʻomia suʻesuʻega faʻapitoa ma suʻesuʻega faʻapitoa aʻo leʻi mafai ona alualu i luma i faʻataʻitaʻiga a le tagata.O ana gaioiga fa'asaina o le kinase, aemaise lava i le Aurora kinases, FLT3, ma le JAK2, ua fa'atūina ai e avea ma sui tauva mo le atina'eina o togafitiga fa'atatau mo le kanesa ma fa'ama'i toto.O ana mea fa'aanti-inflammatory e fa'ailoa mai ai fo'i ni fa'aoga talafeagai i le puleaina o fa'ama'i fa'ama'i fa'ama'i ma fa'ama'i fa'ama'i.Ae ui i lea, e manaʻomia nisi suʻesuʻega e tatala ai lona malosi atoatoa ma iloilo lona saogalemu ma le aoga.