Oloa

N (ε) -trifluoroacetyl-L-lysine o se faʻamatalaga faʻapitoa o le amino acid lysine, lea e puipuia ai le vaega amino epsilon (ε) e se vaega trifluoroacetyl (TFA).O lenei tuufaatasiga e maua ai le faʻaogaina i vaega eseese, aemaise i le peptide synthesis ma suʻesuʻega biochemical.O le tasi faʻaaogaina tele o le N (ε) -trifluoroacetyl-L-lysine o loʻo i totonu o le solid-phase peptide synthesis (SPPS).O peptide e iai sona sao taua i le tele o gaioiga fa'aola, ma o la latou fa'asologa e mana'omia ai le fa'asologa fa'asologa o amino acids.Ole vaega puipuia ole TFA ile vaega ole epsilon amino ole lysine e puipuia ai gaioiga e le mana'omia i le taimi o le faʻavaeina o le peptide ae faʻatagaina isi amino acids e faʻatasi i tulaga manaʻomia.A maeʻa le faʻapotopotoga peptide, e mafai ona filifilia le vaega puipuia o le TFA, ma o le N (ε) -trifluoroacetyl-L-lysine totoe e mafai ona faʻalautele atili e faʻapipiʻi faʻasologa peptide faʻapitoa. N (ε) -trifluoroacetyl-L-lysine o loʻo iai foʻi. fa'aaogaina i su'esu'ega fa'aola kemikolo e su'esu'e ai le fausaga, galuega, ma fegalegaleaiga.E mafai ona avea o se meafaigaluega e suʻesuʻe ai le matafaioi a le lysine o totoe i fegalegaleaiga protein-protein, fegalegaleaiga protein-DNA, ma suiga pe a maeʻa faʻaliliuga.E ala i le faʻalauiloaina o le vaega TFA, e mafai ona faʻaleleia mea tau vailaʻau o le lysine, faʻatagaina mo le suʻesuʻeina o faiga faʻapitoa lysine-mediated i faiga faʻapitoa. faiga e avatu ai fualaau.E ala i le tuʻufaʻatasia o vailaʻau faʻapitoa faʻapitoa i le lysine o totoe e ala i le vaega TFA, e mafai ona faʻateleina le mautu ma le filifilia o le vailaʻau, e oʻo atu ai i le faʻaleleia atili o le aoga ma faʻaitiitia ai aʻafiaga.O lenei taʻiala na suʻesuʻeina i le tuʻuina atu o vailaʻau faʻamaʻi, vailaʻau faʻamaʻi, ma isi togafitiga. I le faʻaopoopoga i ana faʻaoga tuusaʻo, N (ε) -trifluoroacetyl-L-lysine e mafai foi ona faʻaaogaina e fai ma poloka fale mo le tuʻufaʻatasia o isi mea faʻaogaina. .O lona fausaga fa'a-kemikolo tulaga ese ma le fa'agaoioiga e avea ai ma mea fa'afiafia amata po'o le vaeluagalemu mo le tu'ufa'atasiga o molela'au fa'aola lavelave, e aofia ai vaila'au, vaila'au fa'ato'aga, ma mea. mulimulita'i puipuiga lelei.E fautuaina e galue i totonu o se falesuesue e faʻaleleia lelei ma faʻaoga mea e puipuia ai le tagata lava ia, e pei o totigilima ma mata tioata saogalemu. tu'ufa'atasiga, su'esu'ega fa'aola kemikolo, tu'uina atu o vaila'au fa'atatau, ma le fa'aogaina o meaola.O lona malosi e puipuia ai le vaega o le epsilon amino o le lysine e mafai ai ona faʻapipiʻi saʻo le peptide, ae o ana vailaʻau faʻaleleia e mafai ai ona suʻesuʻeina le faʻagasologa o le lysine-mediated.Pe a taulimaina lelei, N(ε)-trifluoroacetyl-L-lysine faʻamaonia e avea o se meafaigaluega aoga i le tele o faʻasaienisi ma alamanuia talosaga.