L-Alanine CAS: 56-41-7 99% Paʻepaʻe tioata paʻepaʻe
Numera Fa'amaumauga | XD90326 |
Igoa Oloa | D-Alanine |
CAS | 338-69-2 |
Fuafua mole | C3H7NO2 |
Molecular Weight | 89.09 |
Fa'amatalaga Teuina | Ambient |
Fa'atonu Fa'asologa o Fa'asologa | 29224985 |
Fa'amatalaga o oloa
Fa'aaliga | Pa'epa'e tioata pa'epa'e |
Su'ega | 98.5 - 101.5% |
Ta'amilosaga fa'apitoa | +13.7 i le +15.1 |
Metala mamafa | <0.0015% |
pH | 5.5 - 7 |
SO4 | <0.03% |
Ma'imau ile Fa'amago | <0.2% |
Uamea | <0.003% |
Toega i luga o le mumu | <0.15% |
Lapo'a La'au | 200um |
Cl | <0.05% |
Tulaga o fa'aleagaga fa'alenatura faifai pea | Leai ni mea filogia |
γ-Glutamyltranspeptidases (γ-GTs) faʻapipiʻi le fusi γ-glutamyl amide o le glutathione ma faʻafeiloaʻi le vaega γ-glutamyl faʻamalolo i le vai (hydrolysis) poʻo le taliaina o amino acids (transpeptidation).O nei enzymes ubiquitous o loʻo i ai se sao taua i le biosynthesis ma le faʻaleagaina o le glutathione, ma le faʻamaʻiina o le xenobiotic.O iinei matou te lipoti atu ai le fausaga tioata 3Å o le Bacillus licheniformis γ-GT (BlGT) ma lona lavelave ma l-Glu.O fausaga o le X-ray e faʻamaonia ai o le BlGT e aʻafia i le N-terminal nucleophilic hydrolase superfamily ma faʻaalia ai o le polotini o loʻo i ai se vaeluaga o loʻo matala e tutusa ma le lipoti mo le enzyme homologous mai Bacillus subtilis, ae ese mai i latou na matauina mo tagata γ-GT ma mo γ-GTs mai isi microorganisms.O faʻamaumauga o loʻo faʻaalia ai o le fusifusia o le l-Glu e faʻaosofia ai le toe faʻatulagaina o le siʻusiʻu C-terminal o le BlGT subunit tele ma faʻatagaina le faʻamaoniaina o se fuifui o toega o le acid e ono aʻafia ai i le faʻalauiloaina o se uamea.O le matafaioi o nei toega i luga o le conformational mautu o BlGT ua suesueina e ala i le faamatalaina o le autoprocessing, gaoioiga enzymatic, kemikolo ma vevela denaturation o fa ala fou mutants tasi.O faʻaiʻuga e faʻaalia ai o le suia o le Asp568 ma le Ala e aʻafia uma ai le autoprocessing ma le faʻatulagaina o le porotini.