Doxorubicin hydrochloride CAS:25316-40-9 99% moli-lanu mumu Crystalline pauta
| Numera Fa'amaumauga | XD90367 |
| Igoa Oloa | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Fuafua mole | C27H29NO11·HCl |
| Molecular Weight | 579.98 |
| Fa'amatalaga Teuina | 2 i le 8 °C |
| Fa'atonu Fa'asologa o Fa'asologa | 29419000 |
Fa'amatalaga o oloa
| VaiAnotusi | ≤ 4.0% |
| pH | 4.0-5.5 |
| Solubility | Solu i totonu: vai, methanol ma isotonic NaCl(aq).Le lelei le solubility i chloroform ma isi solu fa'aletino. |
| Mea Fa'atatau | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Su'ega | 99% |
| Solvents totoe | Acetone ma le ava malosi: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| So'o se isi mea leaga | ≤ 0.5% |
| Aofa'i Fa'aleaga | ≤ 2.0% |
| Crystallinity | E tusa ai ma le USP |
| Fa'aaliga | moli-lanu mumu Crystalline pauta |
| Fa'ailoaga | HPLC |
O tagata mama'i e maua i le P-glycoprotein ma le HER2/neu (HER2) e maua ai le kanesa o le susu e masani ona i ai ni taunuuga le lelei.Ae ui i lea, e leai ni fa'atauga o lo'o maua laina sela o le kanesa o le susu o HER2/P-glycoprotein double-positive, lea e fa'atapula'aina ai su'esu'ega i lenei matā'upu. Matou te lipotia le atina'eina ma le fa'ailogaina o se vaila'au fa'asaina mai le susu HER2 lelei. laina sela o le kanesa e ala i suiga mautu o le ATP-binding cassette (ABC) subfamily B member 1 (ABCB1) gene lea e encoded P-glycoprotein.ABCB1 gene expression level na maualuga atu pe a uma le transfection, lea na taitai atu ai i le faateleina o le 40-faaopoopo i le P-glycoprotein. fa'aaliga.O le mea e malie ai, o le faʻaliliuina o le ABCB1 na taʻitaʻia ai foʻi i sina faʻaopoopoga o le HER2 gene ma le faʻaaliga o le protein.O le felauaiga o le ABCB1 na faʻateleina ai le maualuga o le faʻaaliga o le P-glycoprotein. O le auala o loʻo faʻaogaina iinei mo le atinaʻeina o lenei laina telefoni e talafeagai mo le faʻavaveina o le faʻaogaina o le P-glycoprotein-mediated drug resistance pe a faʻatusatusa i metotia faʻapitoa.O le su'ega in vitro cytotoxicity e ta'u mai ai o lenei laina sela e fa'afeagai ma le tele o vaila'au chemotherapeutic.
