Oloa

Na fausia ata tifaga mucoadhesive o loʻo i ai curcumin-loaded nanoparticles, faʻamoemoe e faʻaumiumi le taimi e nofo ai le vailaʻau i totonu o le gutu ma faʻateleina le faʻaogaina o vailaʻau e ala i le mucosa buccal.O ata tifaga na saunia e ala i le tuʻuina atu i le maeʻa ona tuʻufaʻatasia o curcumin-loaded chitosan-coated polycaprolactone nanoparticles i totonu o vaifofo palasitika chitosan.E eseese molar molar o mucoadhesive polysaccharide chitosan ma fa'aputuga ole plasticizer glycerol sa fa'aogaina e fa'amalieina ai tulaga sauniuni.O ata na maua mai i le fa'aogaina o le chitosan ma le maualuga molar mass chitosan na maua e tutusa ma fetuutuunai.Curcumin-loaded nanoparticles sa laugatasia tufatufa i luga o le ata tifaga, e pei ona molimauina e atomic malosi microscopy ma le maualuga-fofoga fanua-emission fana e suʻesuʻe electron microscopy (FEG-SEM) ata.O su'esu'ega o vaega fa'asolo ata tifaga e fa'aaoga ai le FEG-SEM e fa'aalia ai le iai o nanoparticles i totonu o ata.E le gata i lea, o ata tifaga na faʻamaonia le lelei o le faʻamamaina i le faʻataʻitaʻiina o le saliva solution, faʻaalia ai le maualuga o le fulafula e tusa ma le 80% ma in vitro faʻaumi-pulea tuʻuina atu o curcumin.O nei faʻaiʻuga o loʻo faʻaalia ai o ata mucoadhesive o loʻo i ai nanoparticles e ofoina atu se auala faʻamaonia mo le tuʻuina atu o le curcumin, lea e ono aoga tele i le togafitiga o faʻamaʻi faʻamaʻi e manaʻomia ai le tuʻuina atu o fualaau faasaina.© 2014 Wiley Periodicals, Inc. ma le American Pharmacists Association.