Oloa

Carbamic acid, [(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo -1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester, e taʻua foʻi o lona igoa faʻapitoa, o se vailaʻau faʻalavelave lavelave lea e mafai ona faʻaogaina i vaega eseese, e aofia ai vailaʻau ma vailaʻau. .I totonu o fale gaosi oloa, Carbamic acid, [(1R) -3- [5,6-dihydro-3-(trifluoromethyl) -1,2,4-triazolo [4,3-a] pyrazin-7 (8H) - yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester e mafai ona faʻaaogaina e fai ma mea faʻavauvau mo le faʻapipiʻiina o vailaʻau.O lona fausaga fa'apitoa e mafai ai mo suiga ma fa'atinoga, e mafai ai ona fa'atūina ni sui fou o vaila'au.O le i ai o se vaega trifluoromethyl e faʻaleleia ai le lipofilicity o le faʻapipiʻi, e ono faʻaleleia atili ai lona bioavailability ma faʻateleina lona aoga togafitiga.E le gata i lea, o le vaega o le triazolopyrazine ua lauiloa e iai gaioiga faʻaola, ma avea ai ma faʻataʻitaʻiga matagofie mo le atinaʻeina o vailaʻau. E le gata i lea, Carbamic acid, [(1R) -3- [5,6-dihydro-3-(trifluoromethyl) -1,2, 4-triazolo [4,3-a] pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester e mafai ona maua fa'aoga i vaila'au fa'ato'aga.O le fausaga tulaga ese o le tuufaatasiga ma vaega aoga e mafai ai ona avea ma sui tauva mo le atinaeina o vailaau e tineia ai manu faalafua po o vailaau.O vaega trifluoromethyl ma trifluorophenyl e mafai ona faʻaleleia ai le gaioiga ma le mautu, faʻatagaina mo le taulaʻi ma lelei le pulea o faʻamaʻi faʻamaʻi ma vao i faʻatoʻaga. -(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]- , 1,1-dimethylethyl ester e fa'alautele atu i tala atu o vaila'au ma vaila'au fa'ato'aga.O lona fausaga tulaga ese atonu e talafeagai mo faʻaoga i mea faʻasaienisi, e pei o le atinaʻeina o polymers aoga, tioata vai, poʻo vali.Suiga o le fausaga o le tuufaatasiga e mafai ona taʻitaʻia ai mea e faʻatatau i mea faʻapitoa, e aofia ai mea faʻapitoa, faʻaeletoroni, poʻo faʻainisinia. I le faaiuga, Carbamic acid, [(1R) -3- [5,6-dihydro-3-(trifluoromethyl) -1, 2,4-triazolo [4,3-a] pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester ose fa'alavelave lavelave ma e ono fa'aogaina i vaila'au, vaila'au fa'ato'aga, ma mea fa'asaienisi.O lona fausaga tulaga ese ma vaega fa'atino e ofoina atu avanoa mo le atina'eina o tala fou o fualaau fa'asaina, vailaau fa'asaina, ma mea aoga.Peita'i, e mana'omia nisi su'esu'ega ma su'esu'ega ina ia malamalama atoatoa i lona gafatia ma fa'asilisili ona fa'aoga i pisinisi eseese.