Albendazole Cas: 54965-21-8
| Numera Fa'amaumauga | XD91873 |
| Igoa Oloa | Albendazole |
| CAS | 54965-21-8 |
| Fua molela | C12H15N3O2S |
| Molecular Weight | 265.33 |
| Fa'amatalaga Teuina | 2-8°C |
| Fa'atonu Fa'asologa o Fa'asologa | 29332990 |
Fa'amatalaga o oloa
| Fa'aaliga | Pa'epa'e tioata pa'epa'e |
| Asay | 99% min |
| Liu liusuavai | 208-210 °C |
| mafiafia | 1.2561 (fa'atatau fa'atatau) |
| fa'asino fa'asino | 1.6740 (fa'atatau) |
| solubility | E le mafai ona solu i le vai, e mafai ona solu i le anhydrous formic acid, e matua'i solu i le methylene chloride, toetoe lava a le mafai ona solu ile ethanol (96 pasene). |
| pka | 10.72±0.10(Vailoaina) |
| Suavai Solubility | 0.75mg/L(209 ºC) |
Albendazole o se vailaʻau faʻaaogaina e togafitia ai faʻamaʻi pipisi e mafua mai i parasite.E mafai ona tuʻuina atu e togafitia ai se faʻamaʻi pipisi o le faiʻai (neurocysticercosis) pe mafai foi ona tuʻuina atu e togafitia ai se faʻamaʻi pipisi e mafua ai le manava manava (microsporidiosis).
O se mea e maua mai i le benzimidazole, albendazole o se vailaʻau faʻatasi ma le lautele o alaleo antihelmintic.O loʻo faʻaalia ai se aafiaga antihelmintic e faasaga i cestodes maʻaleʻale ma nematodes e ala i le polokaina o le faagasologa o le kulukose uptake e parasites, lea e faʻaalia i le faʻaitiitia o le glycogen faʻaagaga ma mulimuli ane faʻaititia i le maualuga o le adenosintriphophate.O se taunuuga, ua le toe gaoioi le parasite ma pe.E faʻaaogaina i faʻamaʻi pipisi o Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, ma Trichuris trichiura.Synonyms o lenei fualaau faasaina SKF 62979 ma isi.
Methyl 5-(propylthio)-2-benzimidazolecarbamate (Eskazole,Zentel) o se vailaʻau faʻamaʻi lautele e le o faʻatauina i Amerika i Matu.O lo'o maua mai le gaosimea ile fa'aoga alofa.Albendazole o loʻo faʻaaogaina lautele i le lalolagi atoa mo togafitiga o faʻamaʻi pipisi o le intestinalnematode.E aoga e pei o se tasi-dose togafitiga mo ascariasis, New and Old World hookworm infections, ma trichuriasis.Togafitiga fa'atele fa'atasi ma albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, ma fa'ama'i hydatid.O le aoga o le albendazole e tetee atu ai i anufe (cestodes) e masani lava ona sili atu ona fesuisuiai ma itiiti ifo.
Albendazole e tupu e pei o se paʻepaʻe tioata paʻepaʻe e toetoe lava a le mafai ona faʻafefe i le vai.O le fa'aogaina o le gutu o le albendazole e fa'aleleia e se mea'ai ga'o.O le vailaʻau e oʻo i le vave ma le tele o le metabolism muamua i le sulfoxide, o le mea galue lea i le plasma.O le fa'aumatiaina o le afa-ola ole sulfoxide e mai le 10 i le 15 itula.Ole tele ole biliary excretion ma le enterohepatic recycling ole albendazolesulfoxide e tupu.Albendazole e masani lava ona talia lelei i togafitiga tasi-dose mo nematodes intestinal.O le maualuga, fa'aumi togafitiga e mana'omia mo togafitiga fa'ama'i clonorchiasis orechinococcal e mafai ona i'u ai i a'afiaga leaga e pei o le fa'avaivai o le ponaivi, maualuga o enzymes hepatic, ma le alopecia.
Albendazole ei ai le lautele o alaleo o gaioiga e faasaga i nematodes intestinal ma cestodes, faapea foi ma le ate flukes Opisthorchis sinensis, Opisthorchis viverrini, ma Clonorchis sinensis.Ua faʻaaogaina foi ma le manuia e faasaga ia Giardia lamblia.Albendazole o se togafitiga lelei o le hydatid cyst disease (echinococcosis), aemaise lava pe a faʻatasi ma le praziquantel.E aoga foi i le togafitia o le neurocysticercosis cerebral ma spinal, aemaise lava pe a tuuina atu i le dexamethasone. Albendazole e fautuaina mo togafitiga o gnathostomiasis.
