Oloa

E sefululima platinum (II) -faʻavae metallointercalators ua faʻapipiʻiina e faʻaogaina ai le 1,10-phenanthroline (phen) ligands, e aofia ai le 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) ma dipyrido [3,2-d : 2', 3'-f] quinoxaline (dpq), ma le achiral ethylenediamine (en) ma le chiral ancillary ligands 1S,2S-diaminocyclohexane (S,S-dach) ma le 1R,2R-diaminocyclohexane (R,R-dach) .O latou cytotoxicity i le L1210 murine leukemia cell line na fuafuaina e faʻaaoga ai suʻega faʻalavelave faʻatupulaia.O fa'ameamea sili ona cytotoxic o mea ia o lo'o iai S,S-dach ancillary ligands ma 5-CH3-phen intercalating ligands.E tasi le metallointercalator [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), e faʻaalia ai le 5-10-faʻateleina o le cytotoxicity faʻatusatusa i le cisplatin sui sooupu.Mai suʻesuʻega faʻamaufaʻailoga DNA e foliga mai e leai se eseesega tele i le va o soʻo se uʻamea lavelave, e faʻaalia ai e le o le DNA binding affinity poʻo le auala o le fusifusia / DNA faʻapipiʻi na faia e na o le pau lea o le faʻamoemoega o le cytotoxicity o lenei aiga o le platinum (II) -faʻavae. metallointercalators.