Oloa

(4R-Cis)-1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol -1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate o se faʻapipiʻi faʻatasi ma se faʻalavelave faʻalavelave faʻapitoa.E ui o faʻamatalaga faʻapitoa i luga o le faʻaogaina o lenei vailaʻau e mafai ona faʻatapulaʻaina, e mafai ona tatou faʻatalanoaina ona faʻaogaina e faʻavae i luga o ona foliga faʻavae ma uiga masani o mea faʻapitoa tutusa. e fai ma solubilizing agent.O le Dioxane ose solu masani, aemaise lava i kemisi fa'aletino, aua e fa'afefiloi vai ma e lelei lona soluble mo le tele o molela'au fa'aola.O le iai o se vaega o le dioxane i totonu o lenei fa'aputuga e fa'ailoa mai ai e ono iai ni mea e mafai ona solu.O le suitulaga o le fluorine i mea fa'aola e mafai ona fa'aleleia atili ai a latou mea tau vaila'au, e ono fa'ateleina ai lo latou malosi po'o le bioavailability.O le i ai o se vaega phenylamino carbonyl e mafai ona faʻaalia ai le mafai ona fegalegaleai ma faʻamoemoega o meaola, atonu e taʻitaʻia ai aʻafiaga faʻasoifua maloloina. Faʻavae i luga o nei faʻatulagaga faʻavae, e mafai ona i ai le faʻaogaina o lenei vailaʻau i vailaʻau kemisi poʻo le atinaʻeina o vailaʻau.E mafai ona su'esu'eina e avea o se ta'ita'i fa'atumauina mo le atina'eina o vaila'au fou e fa'atatau i fa'ama'i fa'apitoa.Ae ui i lea, e taua le maitauina o nisi suʻesuʻega e manaʻomia e iloa ai ona mea moni faʻafomaʻi, e aofia ai lona aoga, faiga o gaioiga, ma aʻafiaga e ono aʻafia ai. po'o se vaega i le fa'aogaina o vaila'au.Nitronyl ma pyrrole derivatives ua suʻesuʻeina mo lo latou mafai ona faʻaogaina e avea ma taʻavale faʻasolosolo, faʻamalosi, poʻo poloka faufale mo fausaga sili atu ona faigata.Ae ui i lea, o nei talosaga o le a manaʻomia atili suʻesuʻega ma faʻaleleia atili o metotia faʻapipiʻi. I le aotelega, o le tuufaatasiga (4R-Cis) -1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl) -5-(1-). methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate o loʻo faʻaalia ai le gafatia mo le faʻaaogaina i vailaʻau kemisi, mea fa'asaienisi, po'o le tu'ufa'atasiga o kemikolo.Ae ui i lea, e taua tele le faia o suʻesuʻega lautele e iloilo ai ona meatotino, atiaʻe auala faʻapipiʻi talafeagai, ma fuafua ana faʻaoga patino i vaega taʻitasi.