Oloa

4-Chloro-2-fluoro-3-methoxyphenylboronic acid o se vailaʻau vailaʻau o loʻo i ai faʻaoga eseese i le faʻaogaina o meaola, vailaʻau kemisi, ma mea faʻasaienisi. O se tasi o faʻaoga muamua o le 4-Chloro-2-fluoro-3-methoxyphenylboronic acid i le suiga uamea-catalyzed cross-coupling reactions.E avea o se poloka faufale o le boronic acid, e mafai ai ona fausia le carbon-carbon poʻo le carbon-heteroatom fusi.Mo se faʻataʻitaʻiga, e mafai ona faʻaogaina lenei faʻaogaina i Suzuki-Miyaura cross-coupling reactions, lea e tali atu ai i le aryl poʻo le vinyl halides i lalo o le palladium catalysis e gaosia ai le biaryl compounds.O nei gaioiga faʻasolosolo faʻasolosolo e faʻaaogaina lautele i le tuʻufaʻatasia o meaola lavelave lavelave, e aofia ai vailaʻau ma agrochemicals, faʻapea foʻi ma le fausiaina o mea faʻapitoa. -fluoro-3-methoxyphenylboronic acid e mafai ai le tuʻufaʻatasia o mea faʻapitoa eseese ma mea faʻapitoa.O le chlorine atom e mafai ona avea o se vaega faʻatonu i le suiga o le uʻamea-catalyzed faagasologa, faʻatonuina le tali filifilia i nofoaga patino i totonu o se mole.O le suia o le fluorine e maua ai le lipophilicity fa'aleleia, lea e mafai ona a'afia ai mea tau vailaau fa'asaina ma fa'aleleia atili ai lona bioavailability.O le vaega o le methoxy, i le isi itu, e mafai ona avea o se vaega puipuia pe auai i suiga eseese o vailaʻau. I vailaʻau kemisi, 4-Chloro-2-fluoro-3-methoxyphenylboronic acid ma ona mea e maua mai e fiafia e avea ma sui tauva vailaʻau.O vaega fa'atino e pei o le chlorine ma le fluorine e mafai ona fa'afetaui le feso'ota'iga a le pa'u ma fa'amoemoega fa'aola ma fa'aleleia ana mea tau vaila'au.E le gata i lea, o le vaega o le methoxy e mafai ona faʻaleleia atili le mautu o le metabolic ma fesoasoani i lona lipophility ma le solubility.O nei meatotino e avea ai le 4-Chloro-2-fluoro-3-methoxyphenylboronic acid o se amataga taua mo le atinaʻeina o vailaʻau fou i matāʻupu e pei ole oncology, faʻamaʻi pipisi, ma le mumū. -3-methoxyphenylboronic acid e mafai ona faʻatagaina ai le faʻavaeina o esters boronate mautu, lea na faʻaaogaina i le mamanu o mea e iai mea faʻapitoa.O mea nei e mafai ona fa'aalia ai mea fa'apitoa, fa'aeletonika, po'o mea fa'ata'ita'i, fa'atatau i lo latou tu'ufa'atasiga ma le fausaga.O le tuʻufaʻatasia o le 4-Chloro-2-fluoro-3-methoxyphenylboronic acid poʻo ona mea e maua mai i totonu o nei mea e mafai ona tuʻuina atu galuega faʻapitoa ma faʻaleleia ai a latou faʻatinoga. ona o lona kemisi tele ma le gafatia mo le fatuina o mole mole ma meafaitino.O lana matafaioi i le suiga o le u'amea-catalyzed coupling reactions, tu'ufa'atasia ma mea fa'apitoa o ana vaega fa'atino, ua avea ai ma meafaigaluega taua i le fa'aogaina o meaola ma vaila'au kemisi.E le gata i lea, o le vaega o le boronic acid e mafai ai ona fausia le boronate esters, lea e saofagā i le atinaʻeina o mea faʻapitoa ma mea faʻapitoa.