Oloa

Acetoxy Empagliflozin, e ta'ua fo'i o le empagliflozin acetate, o se fa'afouga o le vaila'au fa'ama'i suka empagliflozin.O le Empagliflozin o loʻo i totonu o le vasega o vailaʻau e taʻua o le sodium-glucose co-transporter 2 (SGLT2) inhibitors, lea e masani ona faʻaaogaina mo le puleaina o le maʻisuka ituaiga 2. E galue le Empagliflozin e ala i le taofiofia o le SGLT2, o se porotini e nafa ma le toe faʻaleleia o le kulukose i fatugaʻo.E ala i le taofiofia o lenei polotini, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one o se vailaʻau faʻalavelave lavelave ma se igoa kemisi umi.E pau i lalo o le vasega o triMethylsilyloxy pyranones, lea e masani ona faʻaaogaina i le tele o faʻasaienisi ma alamanuia applications.One o le faʻaaogaina taua o (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-( (triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one o loʻo avea ma vaega puipuia i le faʻaogaina o meaola.O vaega puipuia o vaega fa'atino le tumau e fa'aoga e puipui ai nofoaga fa'apitoa e fa'agaoioi i luga o se mole mole i le taimi o se fa'alavelave fa'ama'i.I le tulaga o le (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, o vaega triMethylsilyloxy e fai ma vaega puipuia. .I le taimi o se tali, o nei vaega e puipuia nisi vaega galue mai le faia o ni gaioiga e le manaʻomia, e faʻatagaina ai gaioiga e manaʻomia e faʻagasolo malie.A maeʻa le tali, e mafai ona faigofie ona aveese vaega o le triMethylsilyloxy, faʻaalia le vaega muamua o galuega.O le isi faʻaoga o le (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy) Methyl)tetrahydro-2H-pyran-2-one o loʻo i totonu o le tuʻufaʻatasiga o mea faʻapitoa.E mafai ona fa'aaogaina e fai ma poloka faufale e fau ai ni fausaga lavelave.O lona uiga fa'apitoa o vaila'au ma le fa'agaoioiga e avea ai ma meafaigaluega taua i le atina'eina o vaega fou o vaila'au.E mafai e kemisi ona faʻaaogaina (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one e faʻalauiloa ai vaega faʻapitoa poʻo le fatuina o mole mole. scaffolds e suʻesuʻe ai gaioiga faʻaola o mea faʻapipiʻi poʻo le atinaʻeina o fualaau fou.O lona i ai o se vaega galue i totonu o se mole mole e mafai ona tuʻuina atu nisi mea manaʻomia i meafaitino.Mo se faʻataʻitaʻiga, e mafai ona faʻaleleia atili le solubility i solvents faʻapitoa poʻo le faʻaleleia o mea e fai ai ata tifaga, e faʻaaogaina ai i totonu o paʻu poʻo faʻapipiʻi.(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-(( triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ose faʻapitoa faʻapitoa faʻatasi ma faʻaoga faʻaoga i vaega eseese faasaienisi ma alamanuia.O lona gafatia e galue o se vaega puipuia ma avea o se poloka faufale i kemisi synthetic, faʻapea foʻi ma ana faʻaoga faʻapitoa i mea faʻasaienisi, e avea o se vaega taua i le atinaʻeina o mole mole ma mea fou.Ae ui i lea, o ana faʻaoga saʻo ma faʻaoga e mafai ona fesuisuiaʻi, e faʻatatau i manaʻoga faʻapitoa ma sini o se galuega faʻasaienisi poʻo pisinisi.