Oloa

(3R,4R) -1-(tert-Butoxycarbonyl) -4-methylpyrrolidine-3-carboxylic acid, lea e taʻua foi o Boc-4-methylproline, o se vailaʻau vailaʻau faʻaaogaina lautele i le fanua o le faʻaogaina o meaola, aemaise lava i le gaosiga o peptides ma peptidomimetics mo talosaga eseese.O se tasi o faʻaoga autu o le Boc-4-methylproline o se vaega puipuia mo le vaega amino o amino acids i le taimi o le peptide synthesis.O vaega puipuia o ni suiga le tumau e puipuia ai vaega faʻapitoa o mole mole e puipuia ai faʻalavelave e le manaʻomia i le faagasologa o le gaosiga.I le peptide synthesis, o le Boc-4-methylproline o loʻo faʻaaogaina e avea o se vaega puipuia mo le vaega amine, e mafai ai mo le faʻapipiʻiina filifilia o isi amino acids e fausia ai le peptide sequence. tu'ufa'atasiga o mea 'ese'ese fa'atasi ma ni gaioiga fa'ale-natura.I le avea ai o se mea faʻapipiʻi, o loʻo i ai se stereocenter, e maua ai le lua enantiomers: (3R,4R) -Boc-4-methylproline ma (3S,4S) -Boc-4-methylproline.O enantiomer ta'itasi e mafai ona fa'aalia uiga eseese o vaila'au ma fegalegaleai ma fa'amoemoega olaola.I le faʻaaogaina o le Boc-4-methylproline e fai ma mea amata, e mafai ai e chemists ona faʻaogaina le tele o mea faʻapipiʻi chiral mo le mauaina ma le atinaʻeina o fualaau.Ua su'esu'eina nei mea fa'afefiloi mo lo latou gafatia e fai ma vaila'au fa'ama'i fa'ama'i eseese, e aofia ai siama, siama, ma sela o le kanesa.E ala i le suia o le fausaga o le Boc-4-methylproline ma le iloiloina o ana mea e maua mai ai, e mafai e le au suʻesuʻe ona suʻesuʻeina o latou gafatia e avea ma taʻitaʻi taʻitaʻi poʻo scaffold molecules mo fualaau faʻasaina. i le fausiaina o peptidomimetics.Peptidomimetics o mea faʻapipiʻi e faʻataʻitaʻiina le fausaga ma le gaioiga o peptides ae maua le faʻaleleia atili o le mautu ma mea tau vailaau.Boc-4-methylproline e mafai ona avea o se poloka fale i le mamanu ma le tuʻufaʻatasia o peptidomimetics, faʻatagaina mo le atinaʻeina o tala faʻafomaʻi faʻatasi ma le faʻaleleia atili o le bioavailability ma le faʻamoemoega faʻapitoa. O le 4-methylpyrrolidine-3-carboxylic acid, poʻo le Boc-4-methylproline, o se mea faʻapitoa e faʻaaogaina lautele i le faʻaogaina o meaola.O lana matafaioi o se vaega puipuia i le peptide synthesis, faʻapea foʻi ma ana mea faʻapitoa, e avea ma poloka fale taua mo le fausiaina o peptides, peptidomimetics, ma chiral compounds.O mea e maua mai i le Boc-4-methylproline o loʻo suʻesuʻeina mo a latou gaioiga faʻapitoa, lea e aofia ai mea faʻamaʻi, antiviral, ma anticancer.Fa'aauau su'esu'ega ma fa'afouga i le fa'aogaina o le Boc-4-methylproline i le fa'asologa o vaila'au e fesoasoani i le atina'eina o vaila'au fa'afoma'i fou ma fa'aleleia atili ai lo tatou malamalama i faiga fa'aola fa'alavelave.