Oloa

O le 3-tert-Butoxycarbonylphenylboronic acid, lea e lauiloa foi o le Boc-phenylboronic acid, o se mea taua e maua mai i le boronic acid ma le taua tele i le faʻaogaina o meaola ma vailaʻau kemisi. tuufaatasia.O le vaega tert-butyloxycarbonyl (BOC) e masani ona fa'aaogaina e puipuia ai mo sina taimi le vaega fa'atino amine i taimi eseese.E ala i le faʻapipiʻiina o le vaega o le BOC i le amine moiety, o le gaioiga o le amine e faʻaitiitia, faʻatagaina mo filifiliga filifilia i isi tulaga i luga o le mole.O le vaega o le BOC e mafai ona faigofie ona aveese i lalo o tulaga malu, ma faʻaalia ai le faʻaogaina muamua o le amine.O lenei ta'iala kulupu puipuia e mafai ai ona tu'ufa'atasia lelei mole molela'au lavelave, e pei o vaila'au ma mea fa'alenatura. E le gata i lea, o le 3-tert-Butoxycarbonylphenylboronic acid o lo'o avea o se reagent taua mo le fa'avaeina o fusi carbon-carbon.Boronic acids, e aofia ai le Boc-phenylboronic acid, e faigofie ona fausia le boronate esters pe a faʻafeiloaʻi ma nucleophiles, e pei o ava malosi poʻo amines.O nei boronate esters e mafai ona faia ni suiga eseese, e aofia ai Suzuki-Miyaura cross-coupling reactions, Negishi couplings, ma Stille couplings.O nei gaioiga e mafai ai ona fa'atupuina molela'au fa'aola lavelave fa'atasi ai ma fa'asologa o suiga eseese ma vaega fa'atino.O le Boc-phenylboronic acid e sili ona aoga mo le faʻaofiina o le phenylboronic acid moiety i totonu o mole faʻatatau.E mafai ona fegalegaleai fa'atasi le fa'aogaina o le acid boronic ma le diols po'o le boronate ester i vaega fa'atino i mea ola, e mafai ai ona faia le mamanu o le iniseti o le enzyme e fa'avae i le boronate ma le ligands.O le Boc-phenylboronic acid e mafai ona tuʻufaʻatasia i totonu o ni mea faʻapipiʻi laʻititi, peptides, poʻo vailaʻau e tuʻuina atu mea manaʻomia poʻo le faʻaleleia atili o le faʻamoemoega.O nei mea e fa'avae i le boronate ua fa'aalia le manuia i togafitiga o fa'ama'i eseese, e aofia ai le kanesa, ma'i suka, ma le mumū.O lona vaega BOC e avea o se vaega puipuia, e mafai ai ona filifili filifiliga i isi tulaga i luga o le mole.E le gata i lea, o le faʻaogaina o le boronic acid e mafai ai ona faʻapipiʻiina le carbon-carbon bond, faʻafaigofie le tuʻufaʻatasia o molelaʻau faʻapitoa.E le gata i lea, o le Boc-phenylboronic acid e iai sona sao taua i vailaʻau kemisi, lea e faʻaaogaina i le mamanu o le boronate-based enzyme inhibitors ma le receptor ligands.I le aotelega, o le Boc-phenylboronic acid ose mea taua tele e saofagā i le alualu i luma i le kemisi gaosia ma suʻesuʻega suʻesuʻega vailaʻau.