Oloa

O le 2,3-Difluoro-4-ethoxybenzeneboronic acid o se tuufaatasiga e maua ai le aoga i le tele o vaega o kemisi, aemaise lava i le faʻaogaina o meaola ma vailaʻau kemisi.Faatasi ai ma lona fausaga tulaga ese ma le toe gaoioi, ua avea ma poloka fale taua mo le fatuina o molelaula faʻalaʻau lavelave ma vailaʻau vailaʻau.O se tasi o faʻaoga autu o le 2,3-Difluoro-4-ethoxybenzeneboronic acid o loʻo taoto i lona faʻaogaina i faʻasalalauga faʻafefe.Feso'ota'iga feso'ota'iga, e pei o le Suzuki-Miyaura ma le Buchwald-Hartwig so'oga, o ni auala mamana ia mo le fausiaina o fusi carbon-carbon ma carbon-heteroatom.I nei tali, 2,3-Difluoro-4-ethoxybenzeneboronic acid e mafai ona avea o se vaega o le ester boronate, e tali atu i electrophiles eseese (faʻataʻitaʻiga, aryl halides, vinyl halides) i lalo o le faʻaogaina o faʻamalosi talafeagai.O lenei mea e mafai ai le faʻapipiʻiina o mea eseese faʻatasi ma mea faʻapitoa faʻapitoa, e pei o vailaʻau faʻamaʻi poʻo vailaʻau.O le suitulaga o le fluorine e mafai ona fa'aleleia atili ai le mautu, lipophilicity, ma tala'aga pharmacokinetic o vaila'au fa'ala'au, ma avea ai i latou ma sui fa'atau fualaau.O le mea lea, o le faʻaogaina o le 2,3-Difluoro-4-ethoxybenzeneboronic acid e avea o se mea muamua i le tuʻufaʻatasia o vailaʻau e pei o vailaʻau e mafai ona maua ai le avanoa i molelaʻau faʻafefeteina ma le faʻaleleia atili o mea ola ma mea e manaʻomia physicochemical. ,3-Difluoro-4-ethoxybenzeneboronic acid e ofoina atu le faʻaogaina atili i mea faʻaoga.E mafai ona tuʻuina atu i le nucleophilic substitution reactions, faʻatagaina mo le faʻaofiina o vaega galue eseese i le tulaga ethoxy.O lenei mea e mafai ai le faʻatupuina o le faʻapipiʻi e faʻafetaui ana meatotino mo faʻamoemoega faʻapitoa poʻo le faʻalauiloaina o vaega faaopoopo o le eseesega i le faʻasologa o le faletusi mo le suʻeina o vailaʻau. kemisi fa'afoma'i.O lona auai i le faʻaogaina o fesoʻotaʻiga, tuʻufaʻatasia o atoms fluorine, ma derivatization i le tulaga ethoxy ua avea ai ma meafaigaluega taua mo le fausiaina o vailaʻau faʻaola eseese ma faʻaoga vailaʻau.O lona fa'aogaina e mafai ai ona tu'ufa'atasia molela'au lavelave ma faletusi mo le su'esu'eina o vaila'au ma maua ai le avanoa i mea fa'apipi'i fa'alelei ma fa'alelei meatotino.