Oloa

O le tuufaatasiga 2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1, 3(2H) -dione o se mole faʻalaʻau faʻalavelave faʻapitoa e mafai ona faʻaogaina i le fanua o vailaʻau ma vailaʻau.Isoindole derivatives ua lipotia mai o loʻo i ai le tele o vailaʻau faʻafomaʻi, e aofia ai le antitumor, anti-inflammatory, ma antimicrobial activities.O le oxazolidinone moiety, o loʻo faʻatusalia e le 1,3-oxazolidin-5-yl group, ua lauiloa mo ana gaioiga antibacterial.Oxazolidinones ua faʻaaogaina e fai ma vaega taua i vailaʻau faʻamaʻi, aemaise lava i siama faʻamaʻi faʻasaina.O loʻo faʻaalia ai e mafai e le faʻapipiʻi ona i ai le malosi e avea o se mea faʻamaʻi faʻamaʻi. O le i ai o le vaega o le morpholinone, o loʻo faʻatusalia e le vaega 4- (3-oxomorpholin-4-yl) phenyl, e faʻaopoopo atili ai le lavelave i le faʻaogaina o le faʻaogaina.Morpholines ua fa'apipi'iina lautele i vaila'au fa'afoma'i ona o lo latou gafatia e fegalegaleai ai ma fa'amoemoega olaola eseese.O le vaega oxo i luga o le morpholinone e ono mafai ona faʻaleleia le faʻaogaina o fesoʻotaʻiga ma sini faʻapitoa, ma avea ai ma poloka fale taua i le mauaina ma le atinaʻeina o vailaʻau. O le 2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]- 1,3-oxazolidin-5-yl vaega, faʻapipiʻi i le isoindole core, e fausia ai le nofoaga autu galue o le tuufaatasiga.O le faʻatulagaina o vailaʻau faʻapitoa a lenei vaega e taʻu mai ai e mafai ona i ai ni fegalegaleaiga ma mea faʻapitoa e pei o enzymes poʻo ni faʻafeiloaʻiga. I le aotelega, e faʻavae i luga o foliga faʻavae o le tuufaatasiga, e iai le malosi e faʻaalia ai gaioiga faʻafomaʻi i antibacterial, anti-inflammatory, ma isi nofoaga faʻapitoa.Ae ui i lea, o ona faʻaoga maʻoti ma faiga o gaioiga e manaʻomia ona faʻamautinoa e ala i nisi suʻesuʻega, e aofia ai in vitro ma in vivo faʻataʻitaʻiga, e iloilo ai lona aoga ma faʻamatalaga saogalemu. -3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione o loʻo faʻaalia ai folafolaga i matata o vailaʻau. ma vaila'au ona o lona fa'alavelave lavelave ma mea e ono mafai ona maua i vailaau mo togafitiga.O su'esu'ega i le lumana'i e mana'omia e su'esu'e ai ona fa'aoga fa'apitoa, fa'aoga fa'apitoa mo togafitiga, ma le aoga atoa.