1,1-Cyclobutanedicarboxylatodiammineplatinum (II) Cas:41575-94-4
Numera Fa'amaumauga | XD90684 |
Igoa Oloa | 1,1-Cyclobutanedicarboxylatodiammineplatinum (II) |
CAS | 41575-94-4 |
Fuafua mole | C6H12N2O4Pt |
Molecular Weight | 371.25 |
Fa'amatalaga Teuina | 2-8°C |
Fa'atonu Fa'asologa o Fa'asologa | 28439090 |
Fa'amatalaga o oloa
Fa'aaliga | Pa'epa'e i le pa'epa'e pa'epa'e |
Su'ega | 99% |
Vai | ≤0.5% |
Ma'imau ile Fa'amago | ≤0.5% |
Klorida | ≤100ppm |
Mea Fa'atatau | ≤0.25% |
So'o se Fa'aleaga le Fa'ailoaina | ≤ 0.1% |
O isi mea leaga uma | ≤0.5% |
1,1-Cyclobutanedicarboxylic acid | ≤ 0.5% |
Tulaga lua o le platinum complex antineoplastic drugs.Ole alaleo ole antitumor ma le antitumor gaioiga e tutusa ma le cisplatin, ae o le vai solubility e sili atu nai lo le cisplatin, ma o le oona i le fatugaʻo e maualalo foi.E i ai se aafiaga curative lelei i le kanesa mama sela laiti, ovarian kanesa, ulu ma ua squamous cell carcinoma, testicular tuma, lymphoma leaga, ma isi E mafai foi ona faaaoga mo le kanesa faa'a'au, kanesa o le manava, ma isi.
O vaila'au fa'ama'i fa'ama'i fa'ama'i o le platinum lona lua o lo'o i ai le tutusa o galuega ma fa'aoga e pei o le cisplatin.E sili atu le malosi nai lo le cisplatin mo nisi tuma, ma e sili atu le malosi nai lo le cisplatin o se radiosensitizer i lalo o tulaga hypoxic.E masani ona faʻaaogaina mo le kanesa ovarian, kanesa testicular, kanesa mama sela laiti ma le kanesa o le ulu ma le ua.
O le Carboplatin o se vaila'au fa'ama'i fa'ama'i e fa'apalapala i le platinum lea e fa'aleagaina ai le DNA e ala i le fa'atupuina o le intrachain conjugation i toega guanine lata ane.O le aafiaga antitumor o nei vailaʻau e maua e ala i le leiloa o le DNA mismatch repair (MMR vaccine) gaioiga ma le faʻaosoina o le oti cell programmed.