Oloa

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxylic acid ethyl ester ose vailaʻau lavelave ua faʻaalia le gafatia i vaega eseese o vailaʻau kemisi ma suʻesuʻega vailaʻau.O se faʻamatalaga lea o lona faʻaogaina i le tusa ma le 300 upu. O lenei tuufaatasiga, e masani ona taʻua o le ethyl ester derivative o le 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylic acid, e aofia i le vasega o pyrazolo [3,4-c] pyridine derivatives.O nei mea e maua mai ua tosina atu i ai le suʻesuʻeina o vailaʻau ona o lo latou gafatia i vaega eseese o togafitiga. O le tasi faʻaogaina o lenei vailaʻau o loʻo taoto i le matata o suʻesuʻega e puipuia ai le kanesa.Pyrazolo [3,4-c] pyridine derivatives ua faʻaalia le faʻaalia o le anti-proliferative gaioiga e faasaga i le tele o ituaiga o sela o le kanesa.O lo latou gafatia e taofiofia ala faʻapitoa e aʻafia i le tuputupu aʻe o le tuma ma le ola e avea ai i latou ma sui tauva mo le atinaʻeina o vailaʻau faʻamaʻi.O isi suʻesuʻega e manaʻomia e suʻesuʻe ai le faʻaogaina o le gaioiga ma iloilo le aoga o le vailaʻau i nofoaga faʻapitoa ma falemaʻi. E le gata i lea, o lenei vailaʻau ua faʻaalia le folafolaga e avea o se mea e mafai ona faʻamaʻi ai le antibacterial.Ua fa'aalia le gaioiga e tetee atu ai i ituaiga siama eseese, e aofia uma ai siama Gram-positive ma Gram-negative bacteria.O le mafai ona fa'atatau i le tele o fa'ama'i e fa'ailoa mai ai lona gafatia i le fa'ato'ilaloina o siama fa'ama'i fa'asaina, lea ua avea ma popolega fa'alesoifua maloloina i le lalolagi atoa.O isi suʻesuʻega e faʻamaonia e suʻesuʻe ai lona faiga o gaioiga ma iloilo lona aoga i le faʻafefeina o faʻamaʻi siama. E le gata i lea, o pyrazolo [3,4-c] pyridine derivatives, e aofia ai lenei faʻapipiʻi, ua faʻaalia le gafatia i le togafitia o faʻamaʻi pipisi ma faʻamaʻi autoimmune.O le fulafula e tele sona sao i tulaga eseese e pei ole gugu ma le psoriasis.O nei mea e maua mai ua faʻaalia ai mea faʻamaʻi faʻamaʻi e ala i le faʻaogaina o auala faʻapitoa e aʻafia i le tali inflammatory.O lenei mea e taʻu mai ai lo latou gafatia e avea ma vailaʻau faʻamaʻi mo le puleaina o le mumū tumau ma faʻamaʻi faʻapitoa.Ua mae'a su'esu'eina ona o lona a'afiaga i fa'afitauli o le neura e pei o le fa'ama'i o le Alzheimer ma le ma'i Parkinson.E mafai e le fa'apipi'i ona fa'aogaina ni fa'amaliega fa'apitoa ma enzymes o lo'o a'afia i le fa'agasolo o fa'ama'i, e mafai ona ofoina atu a'afiaga o le neuroprotective.Ae ui i lea, e manaʻomia nisi suʻesuʻega ina ia malamalama atoatoa i lona faiga o gaioiga ma iloilo lona aoga i le togafitia o nei faʻafitauli faigata. I le aotelega, 1-(4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1- yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylic acid ethyl ester o loʻo umia le folafolaga i le tele o vaega faʻapitoa, e aofia ai le faʻamaʻi-kanesa, antibacterial, anti-inflammatory , ma faaletonu CNS.O lona gafatia o lo'o taoto i lona gafatia e fa'atatau i ala fa'apitoa ma talitali e aofia ai i nei tulaga.Ae ui i lea, o nisi suʻesuʻega ma suʻesuʻega e manaʻomia e suʻesuʻe atoatoa ai lona gafatia, faʻamaonia ana meatotino, ma iloilo lona saogalemu ma le aoga i totonu o falemaʻi.