Oloa

(αS,3S)-α-[(tert-Butyloxycarbonyl)amino]-2-oxo-3-pyrrolidinepropanoic acid methyl ester, lea e lauiloa foi o Boc-Amino acid methyl ester, o se tuufaatasiga taua i le fanua o le synthesis organic ma peptide kemisi.Boc-Amino acid methyl ester e avea o se ituaiga puipuia o amino acids, lea e faʻaogaina ai le Boc (tert-butyloxycarbonyl) vaega e puipuia ai le vaega amino i taimi o gaioiga.O lenei tuufaatasiga e faʻaaoga muamua i le peptide synthesis e faʻafeiloaʻi ai amino acids patino i filifili peptide.Peptides o filifili pupuu o amino acids e taʻalo taua i faiga faʻaola.Latou te aʻafia i faiga eseese e pei o faʻailoga, faʻatonuga o le enzyme, ma le lagolago faʻavae.Peptide synthesis e aofia ai le faʻapotopotoina faʻasolosolo o amino acids e fatu ai faʻasologa faʻapitoa e faʻataʻitaʻiina peptides faʻanatura poʻo le fatuina o fausaga fou ma mea e manaʻomia. Boc-Amino acid methyl ester e masani ona faʻaaogaina e fai ma poloka fale i le solid-phase peptide synthesis (SPPS), o le o se tasi o auala sili ona faʻaaogaina e fausia ai peptides.I le SPPS, o le filifili peptide o loʻo tuʻufaʻatasia i se auala faʻasolosolo i luga o se lagolago malosi, e masani ona faʻaaogaina se amino acid derivative ma se vaega puipuia le tumau.Boc-Amino acid methyl ester o se mea amata lelei mo SPPS ona o lona mautu, solubility, ma le fetaui ma isi peptide synthesis reagents. I le taimi o le peptide synthesis, o le Boc-Amino acid methyl ester e faʻaopoopoina i le faʻatupuina o le peptide filifili e ala i le faʻavaeina o le amide bond.O le vaega puipuia o le Boc e puipuia ai itu e le manaʻomia ma faʻamautinoa le faʻapipiʻiina o le amino acid i le filifili peptide.O le taimi lava e ausia ai le faʻasologa manaʻomia, e aveese le vaega Boc i lalo o tulaga agamalu, faʻaalia le vaega amino saoloto mo nisi suiga poʻo le peptide characterization. I le faʻaopoopoga i le peptide synthesis, e mafai foi ona faʻaaogaina le Boc-Amino acid methyl ester i le sauniuniga o vailaʻau eseese. mea vavalo, vaila'au fa'ato'aga, ma isi mea fa'aola.O lona taulimaina faigofie, mautu, ma le fetaui ma tulaga masani o le tali atu e avea ai ma poloka fale tele mo le faʻaogaina o meaola. I le aotelega, o le Boc-Amino acid methyl ester o se meafaigaluega taua i le peptide synthesis ma le kemisi faʻalaʻau.O lana matafaioi o se ituaiga puipuia o amino acids e mafai ai mo le faʻapipiʻiina lelei o filifili peptide ma le fausiaina o fausaga peptide eseese mo suʻesuʻega, suʻesuʻega vailaʻau, ma faʻaoga togafitiga.